Risk factors associated with nonalcohol fatty liver disease and fibrosis among patients with type 2 diabetes mellitus
| Autor: | Xiangxin Song, Zhang Li, Hongli Zhao, Xinling Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty endocrine system diseases Alcohol Drinking nonalcoholic hepatitis Observational Study T2DM Blood Pressure Disease Gastroenterology Body Mass Index liver steatosis 03 medical and health sciences 0302 clinical medicine Fibrosis Non-alcoholic Fatty Liver Disease Risk Factors Diabetes mellitus Internal medicine Medicine Humans liver fibrosis business.industry Fatty liver nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Blood pressure Diabetes Mellitus Type 2 Liver 030220 oncology & carcinogenesis Elasticity Imaging Techniques 030211 gastroenterology & hepatology Female Steatosis business Body mass index Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Type 2 diabetes mellitus (T2DM) is closely related to hepatic steatosis and fibrosis. The aim of this study was to analyze the occurrence of hepatic steatosis and fibrosis in patients with T2DM and to explore the risk factors. A total of 629 patients with T2DM were enrolled. Liver stiffness value (LSV) and controlled attenuation parameters (CAP) were measured using Fibroscan. Liver fibrosis was diagnosed when LSV was greater than 7.4 kPa, and advanced liver fibrosis was diagnosed when LSV was greater than 10.6 kPa. Hepatic steatosis diagnosis was made when CAP value was greater than 238 dB/m. Demographic information, physical examination data, and laboratory tests results were collected. The 629 patients were classified into 2 groups by the liver fibrosis and liver steatosis, and then the difference was analyzed. Among patients enrolled, 231 patients were diagnosed as liver fibrosis. The age of the patients in the fibrosis group was significantly greater than that in the non-fibrosis group, and similar trends were observed in the waist–hip ratio (WHR), systolic blood pressure, and diastolic blood pressure. The proportion of smoking and alcoholic consumption was significantly lower in patients with non-fibrosis group. A total of 426 patients were diagnosed with liver steatosis. Body mass index (BMI), WHR, systolic blood pressure, and diastolic blood pressure in patients with steatosis were significantly higher than those in non-steatosis group. We observed that the LSV (P = .042) and CAP value (P |
| Databáze: | OpenAIRE |
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