Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
| Autor: | Seyed Mohammad Mahdi Rasa, Francesco Annunziata, Anna Krepelova, Suneetha Nunna, Omid Omrani, Nadja Gebert, Lisa Adam, Sandra Käppel, Sven Höhn, Giacomo Donati, Tomasz Piotr Jurkowski, Karl Lenhard Rudolph, Alessandro Ori, Francesco Neri |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Inflammation
Stat1 Aging epigenetics Immunity CP: Immunology dietary restriction interferon Immunity Innate General Biochemistry Genetics and Molecular Biology Chromatin Up-Regulation multi-tissue transcriptional network chromatin accessibility Immunologic Receptors aging inflammaging inflammation Humans Interferons Receptors Immunologic Innate |
| ISSN: | 2211-1247 |
| Popis: | Aging is characterized by a chronic low-grade inflammation known as inflammaging in multiple tissues, representing a risk factor for age-related diseases. Dietary restriction (DR) is the best-known non-invasive method to ameliorate aging in many organisms. However, the molecular mechanism and the signaling pathways that drive inflammaging across different tissues and how they are modulated by DR are not yet understood. Here we identify a multi-tissue gene network regulating inflammaging. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. DR ameliorates aging-induced alterations of chromatin accessibility and RNA transcription of the inflammaging gene network while failing to rescue those alterations on the rest of the genome. Our results present a comprehensive understanding of the molecular network regulating inflammation in aging and DR and provide anti-inflammaging therapeutic targets. |
| Databáze: | OpenAIRE |
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