Insula Activity to Visceral Stimulation and Endocrine Stress Responses as Associated With Alexithymia in Patients With Irritable Bowel Syndrome
| Autor: | Motoyori Kanazawa, Mao Yagihashi, Joe Morishita, Shunji Mugikura, Lukas Van Oudenhove, Patrick Dupont, Michiko Kano, Kei Takase, Shin Fukudo, Tomohiko Muratsubaki |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Nociception medicine.medical_specialty Hydrocortisone Adrenocorticotropic hormone Gastroenterology Irritable Bowel Syndrome 03 medical and health sciences Toronto Alexithymia Scale Young Adult 0302 clinical medicine Alexithymia Adrenocorticotropic Hormone Internal medicine Physical Stimulation medicine Humans Affective Symptoms Applied Psychology Irritable bowel syndrome Cerebral Cortex medicine.diagnostic_test business.industry Somatosensory amplification Rectum Fear medicine.disease Anticipation Psychological Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Female business Insula 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychosomatic medicine. 82(1) |
| ISSN: | 1534-7796 |
| Popis: | OBJECTIVE Few studies have investigated associations between alexithymia and physiological mechanisms in psychosomatic diseases. We examined associations between alexithymia and 1) perception and brain processing of visceral stimulation and 2) the endocrine responses to corticotrophin-releasing hormone (CRH) in healthy individuals and patients with irritable bowel syndrome (IBS). METHODS The study included 29 patients with IBS and 35 age- and sex-matched healthy controls (HCs). Alexithymia was measured using the 20-item Toronto Alexithymia Scale (TAS-20). Brain responses to rectal distention and its anticipation were measured by functional magnetic resonance imaging and analyzed at a voxel-level threshold of puncorrected < .001 combined with a cluster-level threshold of pFWE-corrected < .05. On a different day, plasma adrenocorticotropic hormone and cortisol responses after intravenous CRH administration were measured. RESULTS TAS-20 scores did not differ significantly between patients with IBS and HCs (p = .18). TAS-20 scores correlated positively with the individual rectal discomfort thresholds (βrobust = 0.49, p = .03) and negatively with the rating of fear before rectal distention (βrobust = -1.63, p = .04) in patients with IBS but not in HCs. Brain responses to rectal distention in the right insula and other brain regions were positively associated with TAS-20 scores to a greater extent in patients with IBS than in HCs. Individuals with higher TAS-20 scores (both patients with IBS and HCs) demonstrated stronger adrenocorticotropic hormone responses to CRH administration (F(4,224) = 3.54, p = .008). CONCLUSION Higher alexithymia scores are associated with stronger physiological responses, but lower anticipatory fear ratings and higher discomfort thresholds, particularly in patients with IBS. |
| Databáze: | OpenAIRE |
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