Behavioral and physiological effects of a single injection of rat interferon-α on male Sprague–Dawley rats: A long-term evaluation
| Autor: | Catherine Bielajew, Jonathan S. James, Amanda C. Kentner, Maı̈a Miguelez |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Physiology Central nervous system Drinking Alpha interferon Motor Activity Body Temperature Rats Sprague-Dawley Piloerection Lethargy Internal medicine Animals Immunologic Factors Medicine Molecular Biology Interferon alfa Sickness behavior Morning Analysis of Variance Behavior Animal Dose-Response Relationship Drug business.industry General Neuroscience Body Weight Interferon-alpha Hepatitis C medicine.disease Rats medicine.anatomical_structure Endocrinology Neurology (clinical) Stereotyped Behavior business Locomotion Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 1095:96-106 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2006.04.014 |
| Popis: | Interferon-alpha (IFN-alpha) is a cytokine used as a first line of defense against diseases such as cancer and hepatitis C. However, reports indicate that its effectiveness as a treatment is countered by central nervous system (CNS) disruptions in patients. Our work explored the possibility that it may also cause long-term behavioral disruptions by chronicling the behavioral and physiological disturbances associated with a single injection of vehicle, 10, 100, or 1,000 units of IFN-alpha in male Sprague-Dawley rats (n = 5/dose). Following 1 day of locomotor baseline collection, we monitored sickness behaviors (ptosis, piloerection, lethargy, and sleep), food and water intake, body weight, temperature, and motor activity. Observations were recorded 4 days prior to and 4 days following the IFN-alpha injection. Temperature and sickness behaviors were recorded three times daily at 9:00, 15:00, and 21:00 h, and all other indices, once daily. On the injection day, temperature values were highest in the animals receiving the 10-unit IFN-alpha dose 15 min and 13 h post-injection. In the case of sickness behaviors, a significant increase was observed in piloerection in all IFN-alpha groups at each time point measured, while the scores of the rats in the vehicle condition remained unchanged between pre- and post-injection days. Analyses of overall sickness behaviors during morning and night observation periods indicated increased scores in all IFN-alpha groups following injection. Cumulatively, these data suggest that a single IFN-alpha exposure may elicit long-term behavioral disruptions and that its consequences should be thoroughly investigated for its use in clinical populations. |
| Databáze: | OpenAIRE |
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