Inter-observer and segmentation method variability of textural analysis in pre-therapeutic FDG PET/CT in head and neck cancer
| Autor: | Jean-Baptiste Corre, David Bourhis, Yves Gobel, Catherine Guezennec, Philippe Robin, Fanny Orlhac, Ulrike Schick, Pierre-Yves Salaun, Ronan Abgral, Olivier Delcroix |
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| Přispěvatelé: | Service de médecine nucléaire [Brest], Hôpital Morvan [Brest]-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Imagerie Moléculaire in Vivo (IMIV - U1023 - ERL9218), Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de chirurgie de la tête et du cou [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service de Radiothérapie [Brest], Bodescot, Myriam, Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Medical Doctors Intraclass correlation Entropy Health Care Providers Signal-To-Noise Ratio 030218 nuclear medicine & medical imaging Diagnostic Radiology Correlation 0302 clinical medicine Positron Emission Tomography Computed Tomography Medicine and Health Sciences Image Processing Computer-Assisted Segmentation Medical Personnel Tomography Contouring Multidisciplinary medicine.diagnostic_test Physics Radiology and Imaging Squamous Cell Carcinomas Middle Aged Head and Neck Tumors 3. Good health Professions Oncology Positron emission tomography Head and Neck Neoplasms 030220 oncology & carcinogenesis Physical Sciences Carcinoma Squamous Cell Medicine Thermodynamics Engineering and Technology Female Research Article Imaging Techniques Science Standardized uptake value Neuroimaging [SDV.CAN]Life Sciences [q-bio]/Cancer [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine Research and Analysis Methods Carcinomas [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine 03 medical and health sciences Head and Neck Squamous Cell Carcinoma [SDV.CAN] Life Sciences [q-bio]/Cancer Diagnostic Medicine Fluorodeoxyglucose F18 Physicians medicine Humans Signal to Noise Ratio Aged Retrospective Studies Reproducibility business.industry Cancers and Neoplasms Biology and Life Sciences Reproducibility of Results medicine.disease Head and neck squamous-cell carcinoma Computed Axial Tomography Health Care Head and Neck Cancers People and Places Signal Processing Population Groupings business Nuclear medicine Positron Emission Tomography Software Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2019, 14 (3), pp.e0214299. ⟨10.1371/journal.pone.0214299⟩ PLoS ONE, Vol 14, Iss 3, p e0214299 (2019) PLoS ONE, 2019, 14 (3), pp.e0214299. ⟨10.1371/journal.pone.0214299⟩ |
| ISSN: | 1932-6203 |
| Popis: | International audience; AIM: Characterizing tumor heterogeneity with textural indices extracted from 18F-fluorodeoxyglucose positron emission tomography (FDG PET/CT) is of growing interest in oncology. Several series showed promising results to predict survival in patients with head and neck squamous cell carcinoma (HNSCC), analyzing various tumor segmentation methods and textural indices. This preliminary study aimed at assessing the inter-observer and inter-segmentation method variability of textural indices in HNSCC pre-therapeutic FDG PET/CT.MATERIALS AND METHODS: Consecutive patients with HNSCC referred in our department for a pre-therapeutic FDG PET/CT from January to March 2016 were retrospectively included. Two nuclear medicine physicians separately segmented all tumors using 3 different segmentation methods: a relative standardized uptake value (SUV) threshold (40%SUVmax), a signal-to-noise adaptive SUV threshold (DAISNE) and an image gradient-based method (PET-EDGE). SUV and metabolic tumor volume were recorded. Thirty-one textural indices were calculated using LIFEx software (www.lifexsoft.org). After correlation analysis, selected indices' inter-segmentation method and inter-observer variability were calculated.RESULTS: Forty-three patients (mean age 63.8±9.3y) were analyzed. Due to a too small segmented tumor volume of interest, textural analysis could not be performed in 6, 11 and 15 cases with respectively DAISNE, 40%SUVmax and PET-EDGE segmentation methods. Five independent textural indices were selected (Homogeneity, Correlation, Entropy, Busyness and LZLGE). There was a high inter-contouring method variability for Homogeneity, Correlation, Entropy and LZLGE (p |
| Databáze: | OpenAIRE |
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