Post-herpetic neuralgia: further post-mortem studies of cases with and without pain
| Autor: | D van der Kooy, C.P.N. Watson, Cindi Morshead, Ramon J. Evans, J. H. Deck |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Pain Autopsy Myelin Atrophy Fibrosis medicine Humans Axon Pathological Aged Aged 80 and over Staining and Labeling business.industry Histocytochemistry Herpesviridae Infections medicine.disease Microscopy Electron Anesthesiology and Pain Medicine medicine.anatomical_structure Neurology nervous system Sensory Ganglion Spinal Cord Peripheral nervous system Post-herpetic neuralgia Anesthesia Neuralgia Female Neurology (clinical) business |
| Zdroj: | Pain. 44(2) |
| ISSN: | 0304-3959 |
| Popis: | The pathological features associated with post-herpetic neuralgia require further study. We report here 5 cases, 3 with severe post-herpetic neuralgia (PHN) and 2 with no persistent pain. The findings of dorsal horn atrophy and cell, axon and myelin loss with fibrosis in the sensory ganglion were found only in patients with persistent pain. Marked loss of myelin and axons in the nerve and/or sensory root were found in cases with and without pain. Some evidence is presented for a more generalized subacute or chronic inflammatory process which may explain the clinical features of some patients. Further studies will be necessary to fully describe the morbid anatomy of this disorder. |
| Databáze: | OpenAIRE |
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