SARS-CoV-2 Infection and Antibody Seroprevalence among UK Healthcare Professionals Working with Cancer Patients during the First Wave of the COVID-19 Pandemic
| Autor: | Anthony Cooke, A. Bordessa-Kelly, Ieva Budriunaite, Karen McAdam, Nicola L Ainsworth, Rainer Döffinger, Pippa Corrie, David M Favara, Sophie Bossingham, Sally Houghton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Health Personnel Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) education serology 030218 nuclear medicine & medical imaging Serology Young Adult 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Neoplasms Internal medicine Pandemic medicine Humans Seroprevalence Radiology Nuclear Medicine and imaging Pandemics Antibody Aged biology business.industry SARS-CoV-2 Cancer COVID-19 Middle Aged healthcare professionals medicine.disease United Kingdom Vaccination PCR Oncology 030220 oncology & carcinogenesis biology.protein Female Original Article business Delivery of Health Care |
| Zdroj: | Clinical Oncology (Royal College of Radiologists (Great Britain) |
| ISSN: | 1433-2981 0936-6555 |
| Popis: | AIMS: The proportion of UK oncology healthcare professionals (HCPs) infected with SARS-CoV-2 during the COVID-19 pandemic's first wave is unknown. The primary aim of this study was to determine the SARS-CoV-2 infection and seroprevalence rates among HCPs. MATERIALS AND METHODS: Patient-facing oncology HCPs working at three large UK hospitals during the COVID-19 pandemic's first wave underwent polymerase chain reaction (PCR) and antibody testing [Luminex and point-of-care (POC) tests] on two occasions 28 days apart (June-July 2020). RESULTS: In total, 434 HCPs were recruited: nurses (58.3%), doctors (21.2%), radiographers (10.4%), administrators (10.1%); 26.3% reported prior symptoms suggestive of SARS-CoV-2. All participants were PCR negative during the study, but 18.4% were Luminex seropositive on day 1, of whom 42.5% were POC seropositive. Nurses had the highest seropositive prevalence trend (21.3%, P = 0.2). Thirty-eight per cent of seropositive HCPs reported previous SARS-CoV-2 symptoms: 1.9 times higher odds than seronegative HCPs (P = 0.01). Of 400 participants retested on day 28, 13.3% were Luminex seropositive (92.5% previously, 7.5% newly). Thirty-two per cent of initially seropositive HCPs were seronegative on day 28. CONCLUSION: In this large cohort of PCR-negative patient-facing oncology HCPs, almost one in five were SARS-CoV-2 antibody positive at the start of the pandemic's first wave. Our findings that one in three seropositive HCPs retested 28 days later became seronegative support regular SARS-CoV-2 PCR and antibody testing until widespread immunity is achieved by effective vaccination. |
| Databáze: | OpenAIRE |
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