Analysis of plasma multiplex cytokines and increased level of IL-10 and IL-1Ra cytokines in febrile seizures

Autor: Soo Jin Kim, Ran Lee, Jongseok Ha, Sun Whan Bae, Jae Sung Son, Aram Kwon, Kyungmin Kim, Soo-Nyung Kim, Byung Ok Kwak
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Neurology
Febrile seizures
medicine.medical_treatment
Pro-inflammatory cytokines
Immunology
Enzyme-Linked Immunosorbent Assay
Severity of Illness Index
lcsh:RC346-429
Seizures
Febrile
Statistics
Nonparametric
Proinflammatory cytokine
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Febrile seizure
Internal medicine
medicine
Humans
Child
lcsh:Neurology. Diseases of the nervous system
Retrospective Studies
business.industry
Research
General Neuroscience
Infant
Correction
Emergency department
medicine.disease
University hospital
Interleukin-10
Interleukin 10
Interleukin 1 Receptor Antagonist Protein
IL-1Ra
030104 developmental biology
Cytokine
Child
Preschool
IL-10
Fever generation
Cytokines
Female
Anti-inflammatory cytokines
business
030217 neurology & neurosurgery
Zdroj: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-7 (2017)
ISSN: 1742-2094
Popis: Background Febrile seizures are the most common form of childhood seizures. Fever generation involves many cytokines, including both pro- and anti-inflammatory cytokines. Some of these cytokines also induce febrile seizures. We compared cytokine production in children with a fever alone (healthy control group) and febrile seizure children group. Also, we evaluated the cytokine level of children with a fever alone and febrile seizure history. Methods Fifty febrile seizure patients and 39 normal control patients who visited the emergency department of Konkuk University Hospital from December 2015 to December 2016 were included in this study. Blood was taken from the peripheral vessels of children in all groups within 1 h of the seizure, and serum was obtained immediately. Serum samples from patients with only a fever and a febrile seizure history (N = 13) and afebrile seizure controls (N = 12) were also analyzed. Results The serum IL-10 and IL-1Ra levels were significantly higher in the febrile seizure patients than in the fever-only control, fever only with a febrile seizure history, and afebrile seizure groups (p
Databáze: OpenAIRE
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