The Influence of Modernization and Disease on the Gastric Microbiome of Orang Asli, Myanmars and Modern Malaysians
Autor: | Han Ming Gan, Chin Yen Tay, Alex Hwong Ruey Leow, Khean-Lee Goh, Than Than Aye, Win Win Maw, Sylvia Young, S.P. Gunaletchumy, Mya Mya Aye, Sri Ganesh Kalimuthu, Eng Guan Chua, Jamuna Vadivelu, Ahmad Najib Azmi, Kavitha Thevakumar, Mun Fai Loke, Haji Mohd Akmal Bin Dato Dahlan |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Microbiology (medical) Population Beta diversity microbiome Disease Myanmar Biology Modernization theory Microbiology 16S rRNA gene sequencing Article 03 medical and health sciences 0302 clinical medicine Virology medicine Microbiome education lcsh:QH301-705.5 education.field_of_study Orang Asli Helicobacter pylori Malaysian gastric disease biology.organism_classification digestive system diseases 030104 developmental biology lcsh:Biology (General) Alpha diversity beta diversity Gastritis medicine.symptom 030217 neurology & neurosurgery Demography |
Zdroj: | Microorganisms Microorganisms, Vol 7, Iss 6, p 174 (2019) Volume 7 Issue 6 |
ISSN: | 2076-2607 |
Popis: | The present study explored the differences in gastric microbiome between three distinct populations of Southeast Asia. These include the isolated Orang Asli population and modern Malaysians, as well as patients from Myanmar, the least developed country in the region. All 79 subjects recruited in this study had Helicobacter pylori infection. Based on alpha diversity analysis, Orang Asli had the richest and most diverse gastric microbiome, followed by Myanmar and modern Malaysian groups. Beta diversity analysis revealed significant separation of samples between different populations. These observations are likely to be associated with the level of modernization of each population. Our data further suggested increased bacterial species richness and diversity of the gastric microbiome in individuals who were less modernized, particularly in the Orang Asli group, could suppress the growth of H. pylori. In addition, there were significant variations in the gastric microbiome between modern Malaysians with different types of gastric diseases. Notably, Cutibacterium acnes was present at significantly greater abundance level in patients with non-ulcerative dyspepsia than those with peptic-ulcer diagnosis. This suggests that C. acnes may also play a role in gastritis besides H. pylori, which merits further investigation. |
Databáze: | OpenAIRE |
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