Relationship between histopathological features of chemotherapy treated retinoblastoma and P-glycoprotein expression
| Autor: | Miguel N. Burnier, A.L. Caissie, Luiza Helena Fernandes, Maria Cristina Martins, João Pessoa Souza Filho, Clélia Maria Erwenne, Virginia Laura Lucas Torres |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Pathology Retinal Neoplasms medicine.medical_treatment Brachytherapy Enucleation Carboplatin Immunoenzyme Techniques Antineoplastic Combined Chemotherapy Protocols Humans Medicine Neoplasm Invasiveness ATP Binding Cassette Transporter Subfamily B Member 1 Bilateral retinoblastoma Etoposide P-glycoprotein Chemotherapy biology business.industry Retinoblastoma Infant medicine.disease Combined Modality Therapy eye diseases Ophthalmology Vincristine Child Preschool biology.protein Optic nerve Immunohistochemistry Female Histopathology business |
| Zdroj: | Clinical and Experimental Ophthalmology. 33:279-284 |
| ISSN: | 1442-9071 1442-6404 |
| DOI: | 10.1111/j.1442-9071.2005.00991.x |
| Popis: | Background: P-glycoprotein (P-gp) has been identifiedas a possible mediator of chemoresistance in retinoblastoma. Theaim of this study was to determine the expression of P-gp in retinoblastomatreated with chemotherapy prior to enucleation. Methods: Seventeen enucleated specimens of retinoblastomafrom 16 patients were studied. Nine had been treated with chemotherapyalone, and eight had been treated with chemotherapy and other formsof local treatment. Tumour differentiation as well as choroidaland optic nerve invasion were assessed. P-gp immunohistochemicalstaining was performed and evaluated as negative, low or high. Results: Histopathological assessment of thecases showed that 14 of 17 eyes (82.3%) had viable retinoblastomacells. Nine retinoblastomas were considered regressed with a well-differentiatedcomponent, five regressed retinoblastomas had viable cells withpoor differentiation and three retinoblastomas had regressed leavingno viable cells. Sixteen of 17 retinoblastomas were P-gp positive.In the one case with optic nerve invasion and the three cases with massivechoroidal invasion, P-gp expression was found in invading retinoblastomacells. Conclusion: Almost all retinoblastomas expressedP-gp. High levels of P-gp expression might play a role in chemotherapyresistance of retinoblastoma or, conversely, chemotherapymight induce P-gp expression. These results might have an impacton management of bilateral retinoblastoma. |
| Databáze: | OpenAIRE |
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