Penetration of pefloxacin and its desmethyl metabolite into the uroepithelium after a 800-mg single oral dose in human patients
| Autor: | Royer Rj, Moreau Jl, Delavault P, Royer-Morrot Mj, Trackoen G, Lozniewski A |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Metabolite Urinary Bladder Anti-Infective Agents Urinary Administration Oral Urine Microbial Sensitivity Tests Pharmacology Pefloxacin Epithelium chemistry.chemical_compound Pharmacokinetics Anti-Infective Agents medicine Humans Pharmacology (medical) Active metabolite Norfloxacin Antibacterial agent Aged Aged 80 and over Chromatography General Medicine Middle Aged Bioavailability chemistry Regression Analysis Female medicine.drug Chromatography Liquid |
| Zdroj: | European journal of clinical pharmacology. 49(5) |
| ISSN: | 0031-6970 |
| Popis: | Penetration of pefloxacin into the uroepithelium was studied in 20 patients (10 men and 10 women) receiving a single oral dose of 800 mg. Samples of serum, urine, and uroepithelium were taken 1.8 h (mean) after the dose. Pefloxacin and its active metabolite, norfloxacin, were assayed by liquid chromatography, and the microbiologically active compounds were quantified by a microbiological assay. Both procedures were correlated (r0.7); nevertheless, slight differences detected in concentrations depended on the levels of norfloxacin achieved in the biological samples. The serum and tissue concentrations were higher than the concentration of bactericide (4 micrograms.ml-1), except in one case. The uroepithelium concentration of pefloxacin was proportional to the serum concentration (r = 0.79). The urinary concentrations ranged from 1.2 micrograms.ml-1 to 82.4 micrograms.ml-1. The mean norfloxacin/pefloxacin ratios were 3% in serum, 8% in uroepithelium, and 44% in urine. The mean uroepithelium/serum concentration ratios were 1 for pefloxacin and 2.3 for norfloxacin. This result shows that, at a time close to that of the maximum concentration, there is good penetration of pefloxacin and norfloxacin into the uroepithelium. |
| Databáze: | OpenAIRE |
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