Wedge Resection of Tumor Before Lobectomy for Lung Cancer Could Be a No-touch Isolation Technique
| Autor: | Noriyoshi Sawabata, Motoaki Yasukawa, Shigeki Taniguchi, Takeshi Kawaguchi |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Lung Neoplasms business.product_category Cell Separation General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Circulating tumor cell Recurrence Carcinoma Non-Small-Cell Lung Preoperative Care Biomarkers Tumor Humans Medicine Pneumonectomy Lung cancer Aged Neoplasm Staging Aged 80 and over Pharmacology business.industry Middle Aged Neoplastic Cells Circulating Prognosis medicine.disease Tumor site Wedge (mechanical device) Treatment Outcome Surgical Manipulation 030220 oncology & carcinogenesis Biomarker (medicine) Female Non small cell Radiology Tomography X-Ray Computed business Research Article Wedge resection (lung) |
| Zdroj: | In Vivo. 34:779-785 |
| ISSN: | 1791-7549 0258-851X |
| DOI: | 10.21873/invivo.11838 |
| Popis: | Background/aim Circulating tumor cells (CTCs) can be a surrogate biomarker of prospective prognosis. Surgical manipulation can promote the dissemination of CTCs. Prognosis improvement is expected with the no-touch isolation technique (NTIT), preventing surgical manipulation. The Wedge resection of the tumor site before lobectomy could prevent surgical manipulation during lobectomy for non-small cell lung cancer (NSCLC) and reduce the shedding of tumor cells, similar to a NTIT. This study aimed to evaluate the effect of wedge resection technique. Patients and methods A total of 624 resected NSCLC patients were retrospectively analyzed. Patients were divided in two groups: Wedge and Non-Wedge. Overall survival (OS) curves were plotted using the Kaplan-Meier method. Results The 5-year OS rates were 89.9% and 84.0% in the Wedge and Non-Wedge groups, respectively (p=0.033). Conclusion The OS in the Wedge group was significantly better than that in the Non-Wedge group. Wedge resection technique for NSCLC may be a NTIT. |
| Databáze: | OpenAIRE |
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