Bidirectional modulation of hyperalgesia via the specific control of excitatory and inhibitory neuronal activity in the ACC
| Autor: | Jaehoon Shim, Su-Eon Sim, Taehyuk Choi, Chuljung Kwak, Jaehyun Lee, Graham L. Collingridge, Bong-Kiun Kaang, Sukjae Joshua Kang, Min Zhuo |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Pain Threshold Rhodopsin Freund's Adjuvant Optogenetics Inhibitory postsynaptic potential Gyrus Cinguli Mice 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Interneurons medicine Animals Premovement neuronal activity Molecular Biology 030304 developmental biology Inflammation Neurons 0303 health sciences Integrases biology business.industry Research Neural Inhibition Parvalbumins Nociception nervous system Hyperalgesia Freund's adjuvant Excitatory postsynaptic potential biology.protein Chronic Pain medicine.symptom Calcium-Calmodulin-Dependent Protein Kinase Type 2 business Neuroscience 030217 neurology & neurosurgery Parvalbumin |
| Zdroj: | Kang, S J, Kwak, C, Lee, J, Sim, S-E, Shim, J, Choi, T, Collingridge, G L, Zhou, M & Kaang, B-K 2015, ' Bidirectional modulation of hyperalgesia via the specific control of excitatory and inhibitory neuronal activity in the ACC ', Molecular Brain, vol. 8, no. 81, 81 . https://doi.org/10.1186/s13041-015-0170-6 Molecular Brain |
| DOI: | 10.1186/s13041-015-0170-6 |
| Popis: | Neurons in the anterior cingulate cortex (ACC) are assumed to play important roles in the perception of nociceptive signals and the associated emotional responses. However, the neuronal types within the ACC that mediate these functions are poorly understood. In the present study, we used optogenetic techniques to selectively modulate excitatory pyramidal neurons and inhibitory interneurons in the ACC and to assess their ability to modulate peripheral mechanical hypersensitivity in freely moving mice. We found that selective activation of pyramidal neurons rapidly and acutely reduced nociceptive thresholds and that this effect was occluded in animals made hypersensitive using Freund's Complete Adjuvant (CFA). Conversely, inhibition of ACC pyramidal neurons rapidly and acutely reduced hypersensitivity induced by CFA treatment. A similar analgesic effect was induced by activation of parvalbumin (PV) expressing interneurons, whereas activation of somatostatin (SOM) expressing interneurons had no effect on pain thresholds. Our results provide direct evidence of the pivotal role of ACC excitatory neurons, and their regulation by PV expressing interneurons, in nociception. Electronic supplementary material The online version of this article (doi:10.1186/s13041-015-0170-6) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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