Palliative Resection of Primary Tumor in Metastatic Nonfunctioning Pancreatic Neuroendocrine Tumors
| Autor: | Ping Chen, Qijun Shen, Hua Ye, Hong Liu Xu, Qi Zheng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male End results Oncology medicine.medical_specialty Adolescent Neuroendocrine tumors Resection Young Adult 03 medical and health sciences 0302 clinical medicine Palliative resection Internal medicine Epidemiology medicine Humans Propensity Score Pancreas Aged Retrospective Studies Aged 80 and over business.industry Palliative Care Middle Aged medicine.disease Primary tumor United States Confidence interval Pancreatic Neoplasms Neuroendocrine Tumors 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Surgery business Stage iv SEER Program |
| Zdroj: | Journal of Surgical Research. 243:578-587 |
| ISSN: | 0022-4804 |
| Popis: | Whether primary tumor resection is beneficial in patients with metastatic nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs) remains unclear. This study aimed to investigate whether palliative resection of primary tumor affected the survival of patients with stage IV NF-pNETs.We collected data from patients with stage IV NF-pNET registered in the Surveillance, Epidemiology, and End Results database from 2004 to 2015. Risk-adjusted Cox proportional hazard regression analysis and propensity score-matched analysis were used to analyze overall survival (OS) and cancer-specific survival (CSS) of patients.In total, 1974 stage IV NF-pNETs patients were identified, of whom 392 (19.9%) received palliative primary tumor resection. The latter exhibited significantly prolonged OS (hazard ratio = 2.514, 95% confidence interval: 2.081-3.037, P 0.001) and CSS (hazard ratio = 2.634, 95% confidence interval: 2.159-3.213, P 0.001) in multivariate Cox regression analysis. According to propensity score-matched results, patients without primary tumor resection had worse OS and CSS.This study demonstrates that there is a significant correlation between palliative resection of primary tumor and survival benefit. Therefore, resection could be considered as an additional treatment option in this specific patient population. |
| Databáze: | OpenAIRE |
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