Effects of spleen status on early outcomes after hematopoietic cell transplantation
| Autor: | Marcelo C. Pasquini, Manza A. Agovi, David I. Marks, Vikas Gupta, Hillard M. Lazarus, Gorgun Akpek, Richard T. Maziarz, J D Rizzo, Uday R. Popat, O Ringdén, Kenneth R. Cooke, Martin Bornhaeuser, P.L. McCarthy, Karen K. Ballen, Brent R. Logan, Brian J. Bolwell, Vincent T. Ho, Dipnarine Maharaj |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Platelet Engraftment medicine.medical_treatment Splenectomy Spleen Hematopoietic stem cell transplantation stem cell transplantation Gastroenterology Article splenectomy Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans myeloproliferative disease Survival rate Retrospective Studies Transplantation Neutrophil Engraftment business.industry Hematopoietic Stem Cell Transplantation Engraftment Hematology Middle Aged Allografts medicine.disease 3. Good health Survival Rate surgical procedures operative medicine.anatomical_structure Graft-versus-host disease Hematologic Neoplasms 030220 oncology & carcinogenesis Immunology spleen Female business Follow-Up Studies 030215 immunology |
| Zdroj: | Bone marrow transplantation |
| ISSN: | 1476-5365 0268-3369 |
| Popis: | To assess the impact of spleen status on engraftment and early morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT), we analyzed 9,683 myeloablative allograft recipients from 1990 to 2006; 472 had prior splenectomy (SP), 300 splenic irradiation (SI), 1,471 with splenomegaly (SM), and 7,440 with normal spleen (NS). Median times to neutrophil and platelet engraftment were 15 vs. 18 days and 22 vs. 24 days for the SP and NS groups, respectively (p5.7x106/kg improved platelet engraftment at day+28. After adjusting variables by Cox regression, the incidence of graft-versus-host disease (GVHD) and overall survival were not different among groups. Splenomegaly is associated with delayed engraftment while splenectomy prior to HCT facilitates early engraftment without impact on survival. |
| Databáze: | OpenAIRE |
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