Prognostic Factors for Inguinal Lymph Node Involvement and Tumor Recurrence in Squamous Cell Carcinoma of the Penis
| Autor: | Fabian Godoy, Claudia Ochoa, Carolina Pinzón, Daniela Robledo, Angie Ramirez, Sergio Giraldo, Rafael Vargas, Wilfredo Donoso Donoso, Byron Eduardo López De Mesa López, Marino Cabrera, Jorge Forero, J. Gustavo Ramos, José A. De la Hoz-Valle, Sara Peralta, Rodolfo Varela, Andres Calderon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Lymphovascular invasion Urology medicine.medical_treatment lymphovascular invasion 030232 urology & nephrology lcsh:RC870-923 lcsh:Gynecology and obstetrics 03 medical and health sciences 0302 clinical medicine Internal medicine Penile Carcinoma medicine Carcinoma Lymph node lcsh:RG1-991 business.industry Cancer Retrospective cohort study Odds ratio degree of tumor differentiation medicine.disease lcsh:Diseases of the genitourinary system. Urology tumor recurrence medicine.anatomical_structure 030220 oncology & carcinogenesis penile carcinoma Lymphadenectomy business |
| Zdroj: | Urología Colombiana, Vol 29, Iss 02, Pp 084-090 (2020) |
| ISSN: | 2027-0119 |
| Popis: | Introduction Penile carcinoma is an aggressive disease with catastrophic consequences that frequently lead to death. Therefore, further knowledge on the prognostic factors that can help identify patients in need of more aggressive treatments becomes essential. Objective To identify the prognostic factors for lymph node (LN) involvement and tumor recurrence in patients diagnosed with squamous cell carcinoma of the penis (SCCP). Methods A retrospective cohort study was conducted. Patients diagnosed and treated for SCCP at Instituto Nacional de Cancerología between 2008 and 2015 were included in the sample. Cases in which no information on recurrence was available for the follow-up were excluded, as well as patients with no initial pathology and those getting penile reconstructions after cancer.Relevant data was retrieved from the medical records of each patient, and a descriptive analysis was performed. Subsequently, this data was used to apply a logistic regression model to determine the potential clinical and histopathological prognostic factors. Results A total of 104 patients were included in the present study. The average age of the sample was 59 years, while the follow-up averaged 24 months per patient. Inguinal lymphadenectomy was performed on 61 patients (59%) during the follow-up. The logistic regression model showed that lymphovascular invasion (odds ratio [OR]: 6.7; 95% confidence interval [95%CI]: 1.2–35) and poor tumor differentiation (OR: 17; 95%CI: 3.2–92) were associated with tumor recurrence. Likewise, the lymphadenectomy procedures showed that lymphovascular invasion was associated with LN involvement (OR: 3.3; 95%CI: 1.1–10). Conclusion Lymphovascular invasion was the strongest prognostic factor observed in our sample, aiding in the prediction of inguinal LN involvement and tumor recurrence in SCCP patients. |
| Databáze: | OpenAIRE |
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