Incomplete CD4 T cell recovery in HIV-1 infection after 12 months of highly active antiretroviral therapy is associated with ongoing increased CD4 T cell activation and turnover
| Autor: | H. Clifford Lane, Kara B Anthony, Randy Stevens, Julia A. Metcalf, Christian Yoder, Michael A. Polis, Judy Falloon, Rebecca DerSimonian, Irini Sereti, Jan M. Orenstein |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Anti-HIV Agents HIV Infections CD8-Positive T-Lymphocytes Lymphocyte Activation Virus Cohort Studies Immune system Immunopathology Antiretroviral Therapy Highly Active Cytotoxic T cell Humans Pharmacology (medical) biology virus diseases T lymphocyte Middle Aged Viral Load biology.organism_classification CD4 Lymphocyte Count Infectious Diseases Ki-67 Antigen Lentivirus Immunology HIV-1 Female Viral disease Lymph Nodes Viral load |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999). 33(2) |
| ISSN: | 1525-4135 |
| Popis: | To evaluate the relationship between T cell turnover, immune activation, and CD4 recovery in HIV infection, 32 antiretroviral-naive HIV-1-infected patients were studied before and after initiation of highly active antiretroviral therapy (HAART). Elevated CD4 and CD8 T cell turnover (measured by Ki67) in HIV infection decreased with HAART in blood and lymphoid tissue. Increased peripheral CD4 T cell turnover was strongly associated with immune activation even after viral suppression to less than 50 copies/mL (R = 0.8; p |
| Databáze: | OpenAIRE |
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