Wnt10b Inhibits Obesity in ob/ob and Agouti Mice
| Autor: | Sona Kang, Wendy S. Wright, Ormond A. MacDougald, Vedrana S. Susulic, Tyler C. Prestwich, Vernon W. Dolinsky, Kenneth A. Longo, Shian Huey Chiang, Christina N. Bennett, Isabelle Gerin, Charles F. Burant, Catherine Gress |
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| Rok vydání: | 2007 |
| Předmět: |
Blood Glucose
Leptin Male medicine.medical_specialty Panniculitis FGF21 Endocrinology Diabetes and Metabolism Adipose tissue Mice Transgenic Biology Fatty Acid-Binding Proteins Mice Oxygen Consumption Proto-Oncogene Proteins Internal medicine Internal Medicine medicine Animals Glucose homeostasis Obesity Leptin Deficiency Wnt signaling pathway Wnt Proteins Disease Models Animal Endocrinology Adipose Tissue Adipogenesis Agouti Signaling Protein Intercellular Signaling Peptides and Proteins Female Resistin Insulin Resistance Energy Intake |
| Zdroj: | Diabetes. 56:295-303 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db06-1339 |
| Popis: | The Wnt family of secreted signaling molecules has profound effects on diverse developmental processes, including the fate of mesenchymal progenitors. While activation of Wnt signaling blocks adipogenesis, inhibition of endogenous Wnt/beta-catenin signaling by Wnt10b promotes spontaneous preadipocyte differentiation. Transgenic mice with expression of Wnt10b from the FABP4 promoter (FABP4-Wnt10b) have less adipose tissue when maintained on a normal chow diet and are resistant to diet-induced obesity. Here we demonstrate that FABP4-Wnt10b mice largely avert weight gain and metabolic abnormalities associated with genetic obesity. FABP4-Wnt10b mice do not gain significant body weight on the ob/ob background, and at 8 weeks of age, they have an approximately 70% reduction in visceral and subcutaneous adipose tissues compared with ob/ob mice. Similarly, on the lethal yellow agouti (A(y)) background, FABP4-Wnt10b mice have 50-70% less adipose tissue weight and circulating leptin at 5 months of age. Wnt10b-Ay mice are more glucose tolerant and insulin sensitive than A(y) controls, perhaps due to reduced expression and circulation of resistin. Reduced expression of inflammatory cytokines may also contribute to improved glucose homeostasis. |
| Databáze: | OpenAIRE |
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