Evaluation of kidney injury biomarkers in an adult Mexican population environmentally exposed to fluoride and low arsenic levels
| Autor: | Guadalupe Aguilar-Madrid, Carmen González-Horta, Mariana Cárdenas-González, Olivier Barbier, Angel Barrera-Hernández, Luz M. Del Razo, Luz C. Sánchez-Peña, Iván A. Domínguez-Guerrero, Mónica I. Jiménez-Córdova |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Physiology Urine 010501 environmental sciences Kidney Toxicology 01 natural sciences Fluorides chemistry.chemical_compound Medicine Hepatitis A Virus Cellular Receptor 1 biology Trefoil factor 3 Middle Aged Female Kidney Diseases Trefoil Factor-3 Environmental Monitoring Glomerular Filtration Rate Adult Adolescent Urinary system Renal function Risk Assessment Arsenic Young Adult 03 medical and health sciences Predictive Value of Tests Albuminuria Humans Cystatin C Mexico Aged 0105 earth and related environmental sciences Pharmacology Creatinine Clusterin business.industry Albumin Environmental Exposure Cross-Sectional Studies 030104 developmental biology chemistry biology.protein Osteopontin business Biomarkers Water Pollutants Chemical Toxicant |
| Zdroj: | Toxicology and Applied Pharmacology. 352:97-106 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/j.taap.2018.05.027 |
| Popis: | Fluoride (F) is a toxicant widely distributed in the environment. Experimental studies have shown kidney toxicity from F exposure. However, co-exposure to arsenic (As) has not been considered, and epidemiological information remains limited. We evaluated the association between F exposure and urinary kidney injury biomarkers and assessed As co-exposure interactions. A cross-sectional study was conducted in 239 adults (18-77 years old) from three communities in Chihuahua, Mexico. Exposure to F was assessed in urine and drinking water, and As in urine samples. We evaluated the urinary concentrations of albumin (ALB), cystatin-C (Cys-C), kidney injury molecule 1 (KIM-1), clusterin (CLU), osteopontin (OPN), and trefoil factor 3 (TFF-3). The estimated glomerular filtration rate (eGFR) was calculated using serum creatinine (Creat) levels. We observed a positive correlation between water and urine F concentrations (ρ = 0.7419, p 0.0001), with median values of 1.5 mg/L and 2 μg/mL, respectively, suggesting that drinking water was the main source of F exposure. The geometric mean of urinary As was 18.55 ng/mL, approximately 39% of the urine samples had As concentrations above the human biomonitoring value (15 ng/mL). Multiple linear regression models demonstrated a positive association between urinary F and ALB (β = 0.56, p 0.001), Cys-C (β = 0.022, p = 0.001), KIM-1 (β = 0.048, p = 0.008), OPN (β = 0.38, p = 0.041), and eGFR (β = 0.49, p = 0.03); however, CLU (β = 0.07, p = 0.100) and TFF-3 (β = 1.14, p = 0.115) did not show significant associations. No interaction with As exposure was observed. In conclusion, F exposure was related to the urinary excretion of early kidney injury biomarkers, supporting the hypothesis of the nephrotoxic role of F exposure. |
| Databáze: | OpenAIRE |
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