RFID as a new ICT tool to monitor specimen life cycle and quality control in a biobank
| Autor: | Veronica Papa, Antonella Spila, Silvia Riondino, David Della-Morte, Paolo Somma, Jhessica Alessandroni, Raffaele Palmirotta, Mario Roselli, Maria Giovanna Valente, Fiorella Guadagni, Mauro Iacoboni, Patrizia Ferroni, Umberto Nanni |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Quality Control
Cancer Research Biospecimen media_common.quotation_subject Clinical Biochemistry Control (management) Detailed data specimen retrieval Pathology and Forensic Medicine Specimen Handling Translational Research Biomedical 03 medical and health sciences 0302 clinical medicine radio-frequency identification (rfid) Radio Frequency Identification Device Humans Biological Specimen Banks Translational Medical Research Medicine Quality (business) media_common biobank specimen collection business.industry 0402 animal and dairy science Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio 04 agricultural and veterinary sciences 040201 dairy & animal science Data science Biobank Identification (information) Oncology Specimen collection Information and Communications Technology 030220 oncology & carcinogenesis business Settore ING-INF/05 - Sistemi di Elaborazione delle Informazioni |
| Popis: | Background Biospecimen quality is crucial for clinical and translational research and its loss is one of the main obstacles to experimental activities. Beside the quality of samples, preanalytical variations render the results derived from specimens of different biobanks or even within the same biobank incomparable. Specimens collected along the years should be managed with a heterogeneous life cycle. Hence, we propose to collect detailed data concerning the whole life cycle of stored samples employing radio-frequency identification (RFID) technology. Methods We describe the processing chain of blood biosamples that is operative at the biobank of IRCSS San Raffaele, Rome, Italy (BioBIM). We focus on the problem of tracing the stages following automated preanalytical processing: we collected the time stamps of all events that could affect the biological quality of the specimens by means of RFID tags and readers. Results We developed a pilot study on a fragment of the life cycle, namely the storage between the end of the preanalytics and the beginning of the analytics, which is usually not traced by automated tools because it typically includes manual handling. By adopting RFID devices we identified the possible critical time delays. At 1, 3 and 6 months RFID-tagged specimens cryopreserved at -80°C were successfully read. Conclusions We were able to record detailed information about the storage phases and a fully documented specimen life cycle. This will allow us to promote and tune up the best practices in biobanking because i) it will be possible to classify sample features with a sharper resolution, which allows future utilization of stored material; ii) cost-effective policies can be adopted in processing, storing and selecting specimens; iii) after using each aliquot, we can study the life cycle of the specimen with a possible feedback on the procedures. |
| Databáze: | OpenAIRE |
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