Status of Natural Killer Cell Recovery in Day 21 Bone Marrow after Allogeneic Hematopoietic Stem Cell Transplantation Predicts Clinical Outcome
| Autor: | Shun Fujiwara, Norimichi Hattori, Nana Arai, Yui Uto, Megumi Watanuki, Yuta Baba, Maasa Abe, Bungo Saito, Yukiko Kawaguchi, Nobuyuki Kabasawa, Hirotsugu Ariizumi, Tsuyoshi Nakamaki, So Murai, Hiroyuki Tsukamoto, Kouji Yanagisawa, Yohei Sasaki, Hiroshi Harada, Shotaro Shimada |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Transplantation Conditioning Multivariate analysis Adolescent medicine.medical_treatment Cell Hematopoietic stem cell transplantation Natural killer cell Young Adult 03 medical and health sciences 0302 clinical medicine Bone Marrow Internal medicine Humans Transplantation Homologous Medicine Aged Transplantation business.industry Hazard ratio Hematopoietic Stem Cell Transplantation Hematology Middle Aged Confidence interval Killer Cells Natural Treatment Outcome medicine.anatomical_structure 030220 oncology & carcinogenesis Female Bone marrow business Early phase 030215 immunology |
| Zdroj: | Biology of Blood and Marrow Transplantation. 24:1841-1847 |
| ISSN: | 1083-8791 |
| DOI: | 10.1016/j.bbmt.2018.05.007 |
| Popis: | Rapid immune recovery following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is important for clinical outcome prediction. In most studies, immune recovery after allo-HSCT is monitored via peripheral blood. However, few reports regarding the status of absolute lymphocyte subsets in the bone marrow (BM) microenvironment have been undertaken. Therefore, we evaluated the clinical impact of immune recovery in the early period following allo-HSCT using BM samples. We showed that delayed natural killer cell recovery was independently associated with a poor prognosis for overall survival (hazard ratio [HR], 3.07; 95% confidence interval [CI], 1.37- 6.89; P = .007), progression-free survival (HR, 3.42; 95% CI, 1.47-7.94; P = .004), and nonrelapse mortality (HR, 6.68; 95% CI, 1.82-25.0; P = .004) by multivariate analysis. In addition, low NK cell counts were associated with the presence of 1 or more bacterial, viral, or fungal infections. Our results indicate that investigating absolute lymphocyte subsets in BM in the early phase following allo-HSCT can be useful for predicting and improving survival outcomes. |
| Databáze: | OpenAIRE |
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