Microvolt T-Wave Alternans and the Risk of Death or Sustained Ventricular Arrhythmias in Patients With Left Ventricular Dysfunction
| Autor: | Pearila Brickner Namerow, Michael K. Parides, Anne B. Curtis, J. Thomas Bigger, Daniel M. Bloomfield, Timothy Shinn, Elizabeth S. Kaufman, Richard C. Steinman, John M. Fontaine, Jorge M. Davidenko |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Heart disease 030204 cardiovascular system & hematology Risk Assessment Coronary artery disease Electrocardiography Ventricular Dysfunction Left 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine cardiovascular diseases 030212 general & internal medicine Risk factor Ejection fraction business.industry Patient Selection Hazard ratio Arrhythmias Cardiac Atrial fibrillation T wave alternans Middle Aged Prognosis medicine.disease Defibrillators Implantable 3. Good health Treatment Outcome Heart failure cardiovascular system Cardiology Female business Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of the American College of Cardiology. 47(2):456-463 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2005.11.026 |
| Popis: | ObjectivesThis study hypothesized that microvolt T-wave alternans (MTWA) improves selection of patients for implantable cardioverter-defibrillator (ICD) prophylaxis, especially by identifying patients who are not likely to benefit.BackgroundMany patients with left ventricular dysfunction are now eligible for prophylactic ICDs, but most eligible patients do not benefit; MTWA testing has been proposed to improve patient selection.MethodsOur study was conducted at 11 clinical centers in the U.S. Patients were eligible if they had a left ventricular ejection fraction (LVEF) ≤0.40 and lacked a history of sustained ventricular arrhythmias; patients were excluded for atrial fibrillation, unstable coronary artery disease, or New York Heart Association functional class IV heart failure. Participants underwent an MTWA test and then were followed for about two years. The primary outcome was all-cause mortality or non-fatal sustained ventricular arrhythmias.ResultsIschemic heart disease was present in 49%, mean LVEF was 0.25, and 66% had an abnormal MTWA test. During 20 ± 6 months of follow-up, 51 end points (40 deaths and 11 non-fatal sustained ventricular arrhythmias) occurred. Comparing patients with normal and abnormal MTWA tests, the hazard ratio for the primary end point was 6.5 at two years (95% confidence interval 2.4 to 18.1, p < 0.001). Survival of patients with normal MTWA tests was 97.5% at two years. The strong association between MTWA and the primary end point was similar in all subgroups tested.ConclusionsAmong patients with heart disease and LVEF ≤0.40, MTWA can identify not only a high-risk group, but also a low-risk group unlikely to benefit from ICD prophylaxis. |
| Databáze: | OpenAIRE |
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