Tamoxifen-induced estrogen receptor up-regulation in mammary tumor cells is not related to growth inhibition
| Autor: | Guy Leclercq, Nicole Legros, Lu Jin |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
medicine.medical_specialty Antineoplastic Agents Hormonal medicine.drug_class Mammary gland Estrogen receptor Biology Toxicology chemistry.chemical_compound Internal medicine medicine Tumor Cells Cultured Humans Pharmacology (medical) skin and connective tissue diseases Pharmacology Mammary tumor Cell growth Antiestrogen Up-Regulation Tamoxifen medicine.anatomical_structure Endocrinology Oncology chemistry Receptors Estrogen Estrogen Growth inhibition medicine.drug |
| Zdroj: | Cancer chemotherapy and pharmacology. 39(4) |
| ISSN: | 0344-5704 |
| Popis: | Treatment of estrogen receptor (ER)-positive mammary tumors with tamoxifen produces a dramatic accumulation of ER in the cell nucleus. We investigated whether this phenomenon might be related to the antitumor activity of the drug. Five tamoxifen derivatives for which an influence on MCF-7 cell growth had previously been established were tested for that purpose; two of them inhibited growth, one was growth-stimulatory, and the remaining two were without significant effect. At 1 microM all compounds up-regulated ER in the cell nucleus after 3 days of culture, suggesting that the ER accumulation does not predict the response to tamoxifen treatment. An analysis of a tamoxifen-resistant clone (RT x 6 cells) under similar experimental conditions led to the same conclusion: the ER level significantly increased in the presence of tamoxifen and its 4-hydroxy metabolite. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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