Putative Role of MCT1 rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus
| Autor: | Richard B. Kreider, Jon Larruskain, Diego A. Bonilla, Ildus I. Ahmetov, Julen Diaz-Ramirez, Jesús Álvarez-Herms, Alex Martínez-Ascensión, Xavier Ramírez de la Piscina-Viúdez, Adrián Odriozola-Martínez, Arkaitz Castañeda-Babarro |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Population
Physical Therapy Sports Therapy and Rehabilitation Biology RC1200 Polymorphism (computer science) Genotype Orthopedics and Sports Medicine genetics 1000 Genomes Project Allele education QH426 Genetic association endurance education.field_of_study lactate musculoskeletal Athletes biology.organism_classification QP Genotype frequency GV557-1198.995 metabolism performance Demography Sports |
| Zdroj: | Sports, Vol 9, Iss 143, p 143 (2021) Addi. Archivo Digital para la Docencia y la Investigación instname Universidad de Cantabria (UC) Sports Volume 9 Issue 10 |
| ISSN: | 2075-4663 |
| Popis: | Monocarboxylate transporters (MCTs) have been proposed as important mediators of the exchange between lactate (La−) producer and La− recipient (consumer) cells. Previous studies have suggested that the MCT1 A1470T genotype could be related to different physical performance phenotypes. This study followed the guidelines for Strengthening the Reporting of Genetic Association Studies (STREGA) and aimed to evaluate the distribution of the MCT1 polymorphism rs1049434 in endurance-trained athletes compared to the untrained population. Moreover, this study explored the potential influence of the polymorphism alleles phenotypes on high-intensity exercise performance. In a cross-sectional study fashion, a total of 85 triathletes from northern Spain were genotyped for MCT1 rs1049434 and compared to a control group of 107 healthy male participants (1000 Genomes Research Study for Iberian Populations in Spain). All athletes performed a 30 s Wingate all-out test (WAnT) on a cycle ergometer. Peak and mean power (absolute and relative) were measured. After verification of the Hardy–Weinberg equilibrium, the findings indicated that the MCT1 TT genotype was overrepresented in triathletes in comparison to the genotypic frequency of the general Spanish population. No significant associations were found between any MCT1 genotype and peak or mean power performance in the WAnT. Further studies are required to understand the relationship among MCT1 A1470T polymorphism, endurance-trained athletes, and high-intensity performance. The study was supported by the School of Science and Technology at University of the Basque Country (UPV/EHU). The APC was partially funded by the Research Division of DBSS International and the Exercise and Sport Nutrition Laboratory at Texas A&M University. |
| Databáze: | OpenAIRE |
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