Evaluation of transmitted HIV drug resistance among recently-infected antenatal clinic attendees in four Central African countries
| Autor: | Noe Deoudje, Eric Delaporte, Madeleine Mbangue, Jean-Jacques L Moka, Avelin F. Aghokeng, Martine Peeters, Wilfrid S Nambei, Eitel Mpoudi-Ngole, Etienne Mokondji, Laurence Vergne, Marlyse M Peyou-Ndi |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Anti-HIV Agents Population HIV Infections Drug resistance World Health Organization Drug Resistance Multiple Viral Acquired immunodeficiency syndrome (AIDS) Pregnancy Prevalence Humans Medicine Africa Central Pharmacology (medical) Sida education Pharmacology education.field_of_study biology business.industry Transmission (medicine) Data Collection virus diseases HIV Protease Inhibitors biology.organism_classification medicine.disease Virology Infectious Diseases Family medicine Mutation Lentivirus HIV-1 Reverse Transcriptase Inhibitors Female Viral disease business HIV drug resistance Program Evaluation |
| Zdroj: | Scopus-Elsevier ResearcherID |
| ISSN: | 2040-2058 1359-6535 |
| Popis: | Background The rapid expansion of antiretroviral treatment in resource-limited settings is raising concerns regarding the emergence and transmission of HIV drug resistance (HIVDR). We evaluated the extent of transmission of drug-resistant HIV strains in four Central African countries: the Republic of Congo, Central African Republic, Chad and Cameroon. Methods The World Health Organization (WHO) HIVDR threshold survey was implemented in major treatment areas in each country. Pregnant women who were aged Results The prevalence of HIVDR in Brazzaville and Bangui sites could not be classified because the eligible sample number was not reached. HIVDR prevalence was low (Conclusions The moderate HIVDR prevalence found in Yaoundé and Douala indicate that efforts should be made in Cameroon to prevent HIVDR; however, additional surveys are needed to confirm this trend. This study highlighted challenges presented by the WHO methodology, such as additional costs, workload, difficulties in acquiring even small sample numbers and the necessity for better quality assurance of HIV testing and record keeping at antenatal clinics. |
| Databáze: | OpenAIRE |
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