Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1)
| Autor: | Yusuke Nakamura, A. Nagafuchi, T. Muto, Yoichi Furukawa, S. Tsukita, Akira Horii, Shuichi Nakatsuru |
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| Rok vydání: | 1994 |
| Předmět: |
Molecular Sequence Data
Biology Polymerase Chain Reaction Homology (biology) SCN3A Exon AXIN1 SNAP23 Gene expression Genetics Humans Amino Acid Sequence Molecular Biology Gene Genetics (clinical) In Situ Hybridization Fluorescence Base Sequence Protein primary structure Chromosome Mapping DNA Exons Cadherins Molecular biology Blotting Southern Cytoskeletal Proteins alpha Catenin |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0301-0171 |
| Popis: | We have isolated the human α-catenin gene (CTNNAl), which encodes a cadherin-associated protein, and have determined its primary structure and chromosomal localization. The transcript of CTNNAl is 3.4 kb long and consists of 16 coding exons encoding 906 amino acids and at least one 5’ noncoding exon. The 102-kDa predicted protein is the same size as the murine homolog, and the amino acid sequences of the two proteins are 99.2% homologous. Analysis by reverse transcription-PCR revealed that this gene is expressed ubiquitously in normal tissues. It was mapped to chromosome band 5q31 by fluorescent in situ hybridization. |
| Databáze: | OpenAIRE |
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