Intratumoral injection of radioactive holmium-166 microspheres in recurrent head and neck squamous cell carcinoma: preliminary results of first use
| Autor: | Bakker, Robbert C, van Es, Robert J J, Rosenberg, Antoine J W P, van Nimwegen, Sebastiaan A, Bastiaannet, Remco, de Jong, Hugo W A M, Nijsen, Johannes F W, Lam, Marnix G E H, LS Algemene chirurgie, dFAH AVR, dCSCA AVR |
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| Přispěvatelé: | LS Algemene chirurgie, dFAH AVR, dCSCA AVR |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty palliation medicine.medical_treatment Brachytherapy brachytherapy chemistry.chemical_element Injections Intralesional head and neck squamous cell carcinoma 030218 nuclear medicine & medical imaging Microsphere 03 medical and health sciences Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] Holmium 0302 clinical medicine Text mining Recurrence holmium-166 pallation Medicine Humans Radiology Nuclear Medicine and imaging Holmium 166 Aged Retrospective Studies Radioisotopes business.industry Retrospective cohort study General Medicine Original Articles medicine.disease Head and neck squamous-cell carcinoma Microspheres stomatognathic diseases Treatment Outcome chemistry Head and Neck Neoplasms intratumoral treatment 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Radiology business Single session |
| Zdroj: | Nuclear Medicine Communications, 39, 213-221 Nuclear Medicine Communications, 39(3), 213. Lippincott Williams and Wilkins Nuclear Medicine Communications Nuclear Medicine Communications, 39, 3, pp. 213-221 |
| ISSN: | 0143-3636 |
| Popis: | BACKGROUND: Limited treatment options exist for patients with locoregional recurrences of head and neck squamous cell carcinoma (HNSCC). In the palliative setting, a single session, minimally invasive, and relatively safe therapy is desirable. This case series illustrates the feasibility of a direct intratumoral injection of radioactive holmium-166 microspheres (HoMS) in patients as a palliative treatment for recurrent HNSCC. PATIENTS AND METHODS: In this retrospective analysis, patients with already reirradiated irresectable recurrent HNSCC, for whom palliative chemotherapy was unsuccessful or impossible, were offered microbrachytherapy with HoMS. The intratumoral injection was administered manually under ultrasound guidance. Parameters scored were technical feasibility (i.e. administration, leakage, and distribution), clinical response (response evaluation criteria in solid tumors 1.1), and complications (Common Terminology Criteria for Adverse Events 4.3). RESULTS: From 2015 to 2017, three patients were treated. None of the patients experienced adverse events; however, therapeutic effects were minimal. Technical difficulties, including precipitating of microspheres and high intratumoral pressure, resulted in suboptimal distribution of the microspheres. CONCLUSION: Intratumoral injections with HoMS are minimally invasive and relatively safe in palliation of HNSCC patients. Careful patient selection and improved administration techniques are required to provide a more effective treatment. Further investigation of this novel treatment modality should be carried out because of the absence of side effects and lack of other treatment options.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| Databáze: | OpenAIRE |
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