The use of third-party packed red blood cells during ex situ normothermic machine perfusion of organs for transplantation: Underappreciated complexities?
| Autor: | Christopher J.E. Watson, Theodora Foukaneli, Benedict L. Phillips, Chris J. Callaghan, Susan Robinson |
|---|---|
| Přispěvatelé: | Callaghan, Chris J [0000-0003-3334-4152], Watson, Christopher JE [0000-0002-0590-4901], Apollo - University of Cambridge Repository |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Blood transfusion Erythrocytes medicine.medical_treatment 030230 surgery 03 medical and health sciences 0302 clinical medicine ABO blood group system clinical research / practice medicine Immunology and Allergy Pharmacology (medical) organ transplantation in general guidelines Intensive care medicine Transplantation Machine perfusion editorial / personal viewpoint Third party business.industry organ perfusion and preservation Cold Ischemia Organ Preservation Rhesus d Liver Transplantation Perfusion Liver Packed red blood cells business |
| DOI: | 10.17863/cam.58166 |
| Popis: | Ex situ normothermic machine perfusion (NMP) is being used increasingly in the assessment of higher risk deceased donor organs and to facilitate prolonged organ storage. Third-party packed red blood cells (pRBCs) are often used as an oxygen carrier in the perfusate of ex situ NMP. Despite the increasing interest in NMP, comparatively little attention has been paid to the appropriate selection of pRBCs. This includes the choice of ABO blood group and Rhesus D status, the need for special requirements for selected recipients, and the necessity for traceability of blood components. Flushing organs with cold preservation solution after NMP removes the overwhelming majority of third-party allogeneic pRBCs, but residual pRBCs within the organ may have biologically relevant effects following implantation as they enter the recipient's circulation. This review considers these issues, and suggests that national transplant and blood transfusion agencies work together to develop a co-ordinated approach within each country. This is especially important given the possibility of organ re-allocation between centers after ex situ NMP, and the ongoing development of organ perfusion hubs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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