Different Patterns of Helicobacter pylori Adherence to Gastric Mucosa Cells in Children and Adults: An Ultrastructural Study
| Autor: | L B Graff, Jens Blom, Susanne Holck, V Wewer, Peter A. Krasilnikoff, A. Nørgaard, Leif P. Andersen, S O Larsen, A Gernow |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Spirillaceae Bacterial Adhesion Biopsy Pyloric Antrum medicine Gastric mucosa Humans Dyspepsia Child Antrum Aged Aged 80 and over Helicobacter pylori Microvilli biology medicine.diagnostic_test Stomach Age Factors Gastroenterology Histology Middle Aged biology.organism_classification medicine.anatomical_structure Gastric Mucosa Child Preschool Female Gastritis medicine.symptom |
| Zdroj: | Scandinavian Journal of Gastroenterology. 35:1033-1040 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | Infection with Helicobacter pylori in childhood may be the initiation of a lifelong coexistence between microorganisms and epithelial cells resulting in chronic inflammation. The adhesion pattern of H. pylori found in antral biopsies from a group of H. pylori-infected children with recurrent abdominal pain was compared with a group of H. pylori-infected adults suffering from dyspepsia, in an attempt to reveal differences in the type of adhesion.The histology of antrum biopsies and the ultrastructure of adherent H. pylori in biopsies from 26 children (median age, 10.1 years) were compared with organisms in biopsies from 19 adults (median age, 54.4 years).More than 1000 adherent H. pylori were studied and divided into four types of adhesion: 1) contact to microvilli; 2) connection to the plasma membrane via filamentous material; 3) adhesive pedestal formation; and 4) abutting or making a depression in the plasma membrane. Contact to microvilli was significantly higher (69% versus 39%; P = 0.002) in children compared with adults and comprised two-thirds of all adherent organisms in children. The more intimate adhesion types as abutting or adhesive pedestals dominated in adults.These results indicate a change in contact types between H. pylori and gastric epithelial cells in adults compared with children and this may be a natural development in the lifelong infection of humans. |
| Databáze: | OpenAIRE |
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