Thrombotic thrombocytopenic purpura possibly triggered by Graves’ disease
Autor: | Saurabh D Chitnis, Gaby S. Gil, Amandeep Aujla, Ahmed Shady, Tuoyo O. Mene-Afejuku, Andrea Popescu-Martinez, Eder H. Cativo |
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Rok vydání: | 2017 |
Předmět: |
Hemolytic anemia
medicine.medical_specialty Thrombotic microangiopathy Graves' disease Thrombotic thrombocytopenic purpura Case Report 030204 cardiovascular system & hematology Chest pain Microbiology Gastroenterology 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine medicine 030212 general & internal medicine Microvascular occlusion Past medical history business.industry Microangiopathic hemolytic anemia respiratory system medicine.disease Infectious Diseases Parasitology medicine.symptom business |
Zdroj: | Oxford Medical Case Reports |
ISSN: | 2053-8855 |
Popis: | Thrombotic thrombocytopenic purpura (TTP) is a part of a spectrum of thrombotic microangiopathy syndromes which are mainly characterized by platelet aggregation causing microangiopathic hemolytic anemia, thrombocytopenia and microvascular occlusion. In literature, very few cases expressing a direct association between pre-existing Grave’s disease and TTP have been described. A 37-year-old African–American woman with past medical history of Grave’s disease and polysubstance abuse who presented with complaints of dyspnoea at rest and chest pain was diagnosed to have TTP on further evaluation. Patient also showed severely elevated thyroid hormones and suppressed thyroid stimulating hormone levels indicating severe thyrotoxicosis. Initiation of prompt management of TTP and thyrotoxicosis led to a favorable patient outcome. In conclusion, patients presenting with thyrotoxicosis, thrombocytopenia and microangioapthic hemolytic anemia without an alternative cause should be treated and screened for TTP due to the high fatality associated with untreated or untimely detection of this disease. |
Databáze: | OpenAIRE |
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