Extracts of Opuntia humifusa Fruits Inhibit the Growth of AGS Human Gastric Adenocarcinoma Cells
| Autor: | Kun-Young Park, Sahng Wook Hahm, Yong Suk Son, Hyungchul Han, Jieun Park |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cyclin E Cell cycle checkpoint Cell Population Biology 03 medical and health sciences 0302 clinical medicine gastric cancer cell Western blot medicine Cytotoxic T cell education education.field_of_study Nutrition and Dietetics medicine.diagnostic_test Opuntia humifusa Articles Molecular biology 030104 developmental biology medicine.anatomical_structure anticancer activities Biochemistry Apoptosis 030220 oncology & carcinogenesis Cancer cell Food Science |
| Zdroj: | Preventive Nutrition and Food Science |
| ISSN: | 2287-8602 2287-1098 |
| Popis: | Opuntia humifusa (OHF) has been used as a nutraceutical source for the prevention of chronic diseases. In the present study, the inhibitory effects of ethyl acetate extracts of OHF on the proliferation of AGS human gastric cancer cells and the mode of action were investigated. To elucidate the antiproliferative mechanisms of OHF in cancer cells, the expression of genes related to apoptosis and cell cycle arrest were determined with real-time PCR and western blot. The cytotoxic effect of OHF on AGS cells was observed in a dose-dependent manner. Exposure to OHF (100 μg/mL) significantly induced (P |
| Databáze: | OpenAIRE |
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