Design, statistical optimisation, characterisation and pharmacodynamic studies on Pioglitazone hydrochloride floating microparticles

Autor:	Beny Baby, Puri Haritha, N. Vijay Kumar Gupta, Rashmi Mathews, B. Prakash Rao, S. Rajarajan, K. Ramesh
Rok vydání:	2014
Předmět:	Drug Blood Glucose Male Materials science Hydrochloride media_common.quotation_subject Drug Evaluation Preclinical Pharmaceutical Science Bioengineering Pharmacology Eudragit RS chemistry.chemical_compound Crystallinity Colloid and Surface Chemistry medicine Animals Hypoglycemic Agents Physical and Theoretical Chemistry media_common Drug Carriers Chromatography Pioglitazone Organic Chemistry Factorial experiment Controlled release chemistry Pharmacodynamics Delayed-Action Preparations Thiazolidinediones Rabbits medicine.drug
Zdroj:	Journal of microencapsulation. 31(4)
ISSN:	1464-5246
Popis:	The purpose of this study was to develop floating microparticles containing Pioglitazone HCl, for controlled release and perform pharmacodynamic studies. The FTIR and DSC studies revealed that there is no interaction between drug and excipients used. The 22 factorial design was employed to evaluate the effect of drug: polymer (total) and Eudragit RS 100: Eudragit RL 100. The floating microparticles were prepared by solvent evaporation technique. The predicted and actual values of drug release at 1 h, 8 h and drug entrapment were 38.307%, 77.76%, 84.25% and 38.712%, 76.237% and 84.62%, respectively. XRD and SEM studies showed reduced crystallinity of drug and spherical microparticles. Buoyancy studies revealed good floating of particles for 12 h. Pharmacodynamic studies showed significant reduction in blood glucose levels in male New Zealand rabbits. The results demonstrate the feasibility of the factorial design in successfully developing floating microparticles of Pioglitazone HCl for controlled ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7879d66399a75ef9a7a2d89c6218b9f https://pubmed.ncbi.nlm.nih.gov/24697182 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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