Nontuberculous mycobacterial adenitis: Effectiveness of chemotherapy following incomplete excision
| Autor: | Maxwell S. McCormick, R W Clarke, Matthew Jones, David Lloyd, Mohommed I Tawil, John C. Cooper, J. Brian S. Coulter |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Rifabutin medicine.medical_treatment Azithromycin Mycobacterium Lymphadenitis Incision and drainage medicine Humans Parotid Gland Knee Child Postoperative Care Wound Healing Chemotherapy biology business.industry Extremities General Medicine Adenitis biology.organism_classification medicine.disease Combined Modality Therapy Response to treatment Curettage Anti-Bacterial Agents Surgery Child Preschool Face Pediatrics Perinatology and Child Health Female Nontuberculous mycobacteria business Neck medicine.drug |
| Zdroj: | Acta Paediatrica. 95:182-188 |
| ISSN: | 0803-5253 |
| DOI: | 10.1080/08035250500331056 |
| Popis: | Background: Management of lymphadenopathy caused by nontuberculous mycobacteria (NTM) is primarily surgical. Where this cannot achieve sufficient clearance of infected nodes, chemotherapy is often given. Aim: This study compared results of surgery alone with surgery followed by chemotherapy in instances where there was incomplete surgical removal of diseased tissue. Methods: Chemotherapy comprised azithromycin 10 mg/kg and rifabutin 6 mg/kg both given once daily for 6 mo. Ninety-eight children with NTM infection were seen in the period 1990-2004. Sixty-eight cases with adenopathy where "time to healing" (discharge stopped and inflammation settled) was known were available to compare response to treatment. Results : The median ( range) "time to healing" in weeks for 43 patients who had surgery alone was: incision and drainage (ID excision 3 (1-28) (n = 22); and from the last operation of multiple (repeat) surgery 3 (1-40) (n = 11). For 25 patients who required chemotherapy in addition to surgery, the median ( range) "time to healing" in weeks was I&D/curettage 10 (1-40) (n = 17), excision 14 (8-20) (n = 2) and multiple surgery 29 (2-88) (n = 6). Conclusion: In children with adenitis due to NTM, where surgical resection is followed by continued discharge and inflammation, chemotherapy should be considered before further surgery is undertaken. |
| Databáze: | OpenAIRE |
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