Antifungal dimeric chalcone derivative kamalachalcone E fromMallotus philippinensis
| Autor: | Santosh G. Tupe, Macchindra Gulabrao Chandgude, Mukund V. Deshpande, Roshan R. Kulkarni, Swati P. Joshi, Dhiman Sarkar, Suwarna P. Gample |
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| Rok vydání: | 2013 |
| Předmět: |
Chalcone
Antifungal Agents Stereochemistry India Microbial Sensitivity Tests Plant Science Biochemistry Analytical Chemistry Aspergillus fumigatus Inhibitory Concentration 50 chemistry.chemical_compound Chalcones Yeasts Acetone Humans Nuclear Magnetic Resonance Biomolecular Cryptococcus neoformans Leukemia Molecular Structure biology Plant Extracts Organic Chemistry Euphorbiaceae Fungi biology.organism_classification chemistry Fruit Mallotus Drug Screening Assays Antitumor Growth inhibition Two-dimensional nuclear magnetic resonance spectroscopy Rottlerin |
| Zdroj: | Natural Product Research. 28:245-250 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2013.843178 |
| Popis: | From the red coloured extract (Kamala) prepared through acetone extraction of the fresh whole uncrushed fruits of Mallotus philippinensis, one new dimeric chalcone (1) along with three known compounds 1-(5,7-dihydroxy-2,2,6-trimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one (2), rottlerin (3) and 4'-hydroxyrottlerin (4) were isolated. The structure of compound 1 was elucidated by 1D and 2D NMR analyses that included HSQC, HMBC, COSY and ROESY experiments along with the literature comparison. Compounds 1-4 were evaluated for antifungal activity against different human pathogenic yeasts and filamentous fungi. The antiproliferative activity of the compounds was evaluated against Thp-1 cell lines. Compounds 1 and 2 both exhibited IC50 of 8, 4 and 16 μg/mL against Cryptococcus neoformans PRL518, C. neoformans ATCC32045 and Aspergillus fumigatus, respectively. Compound 4, at 100 μg/mL, showed 54% growth inhibition of Thp-1 cell lines. |
| Databáze: | OpenAIRE |
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