Uridine treatment prevents myocardial injury in rat models of acute ischemia and ischemia/reperfusion by activating the mitochondrial ATP-dependent potassium channel
| Autor: | Valentina V. Bulion, Galina D. Mironova, Olga M. Rodionova, Irina B. Krylova, Natalia R. Evdokimova, M. I. Shigaeva, Elena N. Selina, Natalia V. Belosludtseva |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Potassium Channels Necrosis Antioxidant Science medicine.medical_treatment Cardiology Ischemia Myocardial Reperfusion Injury Uridine Triphosphate Pathogenesis Pharmacology Biochemistry Antioxidants Uridine Diphosphate Article chemistry.chemical_compound Adenosine Triphosphate Tachycardia medicine Animals Rats Wistar Uridine Multidisciplinary Chemistry Activator (genetics) Myocardium Arrhythmias Cardiac Hypoxia (medical) medicine.disease Potassium channel Disease Models Animal Acute Disease Ventricular Fibrillation Medicine Lipid Peroxidation medicine.symptom Reperfusion injury |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-96562-7 |
| Popis: | The effect of uridine on the myocardial ischemic and reperfusion injury was investigated. A possible mechanism of its cardioprotective action was established. Two rat models were used: (1) acute myocardial ischemia induced by occlusion of the left coronary artery for 60 min; and (2) myocardial ischemia/reperfusion with 30-min ischemia and 120-min reperfusion. In both models, treatment with uridine (30 mg/kg) prevented a decrease in cell energy supply and in the activity of the antioxidant system, as well as an increase in the level of lipid hydroperoxides and diene conjugates. This led to a reduction of the necrosis zone in the myocardium and disturbances in the heart rhythm. The blocker of the mitochondrial ATP-dependent potassium (mitoKATP) channel 5-hydroxydecanoate limited the positive effects of uridine. The data indicate that the cardioprotective action of uridine may be related to the activation of the mitoKATP channel. Intravenously injected uridine was more rapidly eliminated from the blood in hypoxia than in normoxia, and the level of the mitoKATP channel activator UDP in the myocardium after uridine administration increased. The results suggest that the use of uridine can be a potentially effective approach to the management of cardiovascular diseases. |
| Databáze: | OpenAIRE |
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