Interval-censored survival analysis of mild traumatic brain injury with outcome based neuroimaging clinical applications
| Autor: | Mike Kapostasy, Leon Ma, Logan R. Ranzenberger, Alan Rodriguez, Enrico Fazzini, Amanda Hertzler, Thomas Knoblauch, Andrew Nguyen, Hallie Taylor, Ruslan Nam, Travis Snyder, Taylor Vickery, Yolanda Zhang, Sami Musallam, John Peralta, Alex Asturias, Cheryl Vanier, Shaunaq Parikh, Trisha Pandey |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Traumatic brain injury business.industry General Medicine medicine.disease Outcome (game theory) 030218 nuclear medicine & medical imaging lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Neuroimaging medicine In patient Radiology Presentation (obstetrics) lcsh:Sports medicine business lcsh:RC1200-1245 lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030217 neurology & neurosurgery Mri findings Survival analysis Diffusion MRI |
| Zdroj: | Journal of Concussion, Vol 4 (2020) |
| ISSN: | 2059-7002 |
| Popis: | ObjectiveThe purpose of this study was to assess the relationship between MRI findings and clinical presentation and outcomes in patients following mild traumatic brain injury (mTBI). We hypothesize that imaging findings other than hemorrhages and contusions may be used to predict symptom presentation and longevity following mTBI.MethodsPatients (n = 250) diagnosed with mTBI and in litigation for brain injury underwent 3T magnetic resonance imaging (MRI). A retrospective chart review was performed to assess symptom presentation and improvement/resolution. To account for variable times of clinical presentation, nonuniform follow-up, and uncertainty in the dates of symptom resolution, a right censored, interval censored statistical analysis was performed. Incidence and resolution of headache, balance, cognitive deficit, fatigue, anxiety, depression, and emotional lability were compared among patients. Image findings analyzed included white matter hyperintensities (WMH), Diffusion Tensor Imaging (DTI) fractional anisotropy (FA) values, MR perfusion, auditory functional MRI (fMRI) activation, hippocampal atrophy (HA) and hippocampal asymmetry as defined by NeuroQuant ® volumetric software.ResultsPatients who reported LOC were significantly more likely to present with balance problems (p ConclusionThis analysis demonstrates the utility of clinical data analysis using interval-censored survival statistical technique in head trauma patients. Strong statistical associations between neuroimaging findings and aggregate clinical outcomes were identified in patients with mTBI. |
| Databáze: | OpenAIRE |
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