Efficacy of ultrasonography and Tc-99m MIBI SPECT/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidism

Autor: X. Lv, Ruijun Guo, Mulan Jin, Wei Zhao, Ruigang Lu, Xiang Zhou, Bojun Wei, Chun Zhang, Li Yin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Parathyroidectomy
Primary Hyperthyroidism
Adenoma
Adult
Male
Technetium Tc 99m Sestamibi
Single Photon Emission Computed Tomography Computed Tomography
Adolescent
endocrine system diseases
medicine.medical_treatment
Primary hyperparathyroidism
Parathyroid hormone
030209 endocrinology & metabolism
03 medical and health sciences
Young Adult
0302 clinical medicine
Preoperative Care
medicine
Medical technology
Humans
Radiology
Nuclear Medicine and imaging
R855-855.5
Tc-99m MIBI SPECT/CT
Parathyroid adenoma
Aged
Retrospective Studies
Ultrasonography
business.industry
Research
Retrospective cohort study
Middle Aged
medicine.disease
Hyperparathyroidism
Primary
medicine.anatomical_structure
Parathyroid Neoplasms
030220 oncology & carcinogenesis
Parathyroid gland
Female
Radiopharmaceuticals
business
Nuclear medicine
Zdroj: BMC Medical Imaging, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Medical Imaging
ISSN: 1471-2342
Popis: BackgroundPrimary hyperparathyroidism (PHPT) results from an excess of parathyroid hormone (PTH) produced from an overactive parathyroid gland. The study aimed to explore the sonographic features of parathyroid adenomas and assess the diagnostic performance of ultrasonography (US) and Tc-99m MIBI SPECT/CT for preoperative localization of parathyroid adenomas.MethodsA total of 107 patients were enrolled in this retrospective study who had PHPT and underwent parathyroidectomy. Of the 107 patients, 97 performed US and Tc-99m MIBI SPECT/CT examinations for preoperative localization of parathyroid nodules. The sensitivity and accuracy of each modality were calculated.ResultsIn this study, residual parathyroid sign and polar vascular sign were identified as characteristic US features of parathyroid adenomas. These manifestations were closely related to the size of the abnormal parathyroid lesions. Among the 108 parathyroid nodules from 97 patients with PHPT, the sensitivity and accuracy of US for locating the parathyroid nodules were significantly higher than those of Tc-99m MIBI SPECT/CT (93.0% vs. 63.0% and 88.0% vs. 63.0% respectively; χ2 = 26.224, 18.227 respectively, P 2 = 33.410, 21.587 respectively, P 2 = 0.866, 0.187 respectively, P = 0.352 and 0.665).ConclusionsUS shows significantly better sensitivity and accuracy for localization of parathyroid adenomas than Tc-99m MIBI SPECT/CT. However, US combined with Tc-99m MIBI SPECT/CT is of great clinical value in the preoperative localization of parathyroid nodules in patients with PHPT.
Databáze: OpenAIRE
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