Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation
| Autor: | Xingxing An, Ann Marie Zavacki, Lisbeth Berrueta, Dennis Muñoz Vergara, Peter M. Wayne, Helene M. Langevin, Colleen Carmody |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
030506 rehabilitation
Future studies Swine Carrageenan induced inflammation Localized inflammation Physical Therapy Sports Therapy and Rehabilitation Lumbar vertebrae Pharmacology Carrageenan Article Lesion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Muscle Stretching Exercises medicine Animals Inflammation Lumbar Vertebrae business.industry Mind-Body Therapies Rehabilitation Therapeutic effect Disease Models Animal medicine.anatomical_structure Treatment Outcome chemistry Human anatomy Feasibility Studies Spinal Diseases medicine.symptom 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Am J Phys Med Rehabil |
| ISSN: | 1537-7385 |
| Popis: | Objective Active stretching of the body is integral to complementary mind-body therapies such as yoga, as well as physical therapy, yet the biologic mechanisms underlying its therapeutic effects remain largely unknown. A previous study showed the impact of active stretching on inflammatory processes in rats. The present study tested the feasibility of using a porcine model, with a closer resemblance to human anatomy, to study the effects of active stretching in the resolution of localized inflammation. Design A total of 12 pigs were trained to stretch before subcutaneous bilateral Carrageenan injection in the back at the L3 vertebrae, 2 cm from the midline. Animals were randomized to no-stretch or stretch, twice a day for 5 mins over 48 hrs. Animals were euthanized for tissue collection 48 hrs postinjection. Results The procedure was well tolerated by the pigs. On average, lesion area was significantly smaller by 36% in the stretch group compared with the no-stretch group (P = 0.03). Conclusion This porcine model shows promise for studying the impact of active stretching on inflammation-resolution mechanisms. These results are relevant to understanding the stretching-related therapeutic mechanisms of mind-body therapies. Future studies with larger samples are warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|