Restoration of SOCS3 suppresses human lung adenocarcinoma cell growth by downregulating activation of Erk1/2, Akt apart from STAT3
| Autor: | Jia-xin Min, Yin-bin Xiao, Pin Qian, Zubin Yu, Li Bai, Guisheng Qian, Guansong Wang, Chunxue Bai |
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| Rok vydání: | 2008 |
| Předmět: |
MAPK/ERK pathway
Male STAT3 Transcription Factor Lung Neoplasms medicine.medical_treatment Mice Nude Suppressor of Cytokine Signaling Proteins Biology Adenocarcinoma Transfection Mice Cell Line Tumor medicine Animals Humans SOCS3 STAT3 Protein kinase B PI3K/AKT/mTOR pathway A549 cell Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 digestive oral and skin physiology Cell Biology General Medicine Cell biology Cytokine Suppressor of Cytokine Signaling 3 Protein Cancer research biology.protein Signal transduction Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | Cell biology international. 33(9) |
| ISSN: | 1095-8355 |
| Popis: | SOCS3 is regarded as a major negative regulator of STAT3. Recent evidence indicates that SOCS3 regulates strength and duration of other signaling pathways including ras/ERK1/2/MAPK, PI3-K/Akt in non-malignant cells. The repression or silence of SOCS3 expression in a few tumor types has led to speculation that loss of SOCS3 gene is closely related to deregulation of multiple signal pathways during tumorigenesis. However, apart from STAT3, little is known in malignant cells about the mechanism by which SOCS3 modulates other intracellular signal cascades such as Erk1/2 and Akt, whose aberrant activation has been implicated in many human tumors. Expression of SOCS3 proved deficient in human lung adenocarcinoma A549 cells, and forced expression of SOCS3 resulted in growth inhibition. Growth suppression due to SOCS3 was associated with attenuated activation of Erk1/2, Akt as well as STAT3. The results suggested that SOCS3, as negative regulators of cytokine signaling, might maintain homeostasis by regulating multiple signaling pathways and reverse cell malignant behavior. |
| Databáze: | OpenAIRE |
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