Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy
| Autor: | Tiemin Liu, Philipp E. Scherer, Ningyan Zhang, Christine M. Kusminski, Alexandre Caron, Na Li, Hui Deng, Kai Sun, Jia Sun, Zhuzhen Zhang, Zhenyan He, Yingfeng Deng, Robbie D. Schultz, Kevin W. Williams, Angela K. Odle, Charlotte E. Lee, Gwen V. Childs, Joel K. Elmquist, Min Kim, Ruth Gordillo, Shangang Zhao, Yi Zhu, Qingzhang Zhu, Zhiqiang An, Wei Xiong |
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| Rok vydání: | 2019 |
| Předmět: |
Leptin
0301 basic medicine medicine.medical_specialty Physiology medicine.medical_treatment Mice Inbred Strains Context (language use) Article Eating Mice 03 medical and health sciences 0302 clinical medicine Weight loss Diabetes mellitus Internal medicine Weight Loss medicine Animals Insulin Obesity Molecular Biology business.industry digestive oral and skin physiology Cell Biology medicine.disease Antibodies Neutralizing Weight Reduction Programs 030104 developmental biology Endocrinology Hypothalamus Insulin Resistance medicine.symptom Energy Metabolism business Weight gain hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Cell Metab |
| ISSN: | 1550-4131 |
| DOI: | 10.1016/j.cmet.2019.08.005 |
| Popis: | The physiological role of leptin is thought to be a driving force to reduce food intake and increase energy expenditure. However, leptin therapies in the clinic have failed to effectively treat obesity, predominantly due to a phenomenon referred to as leptin resistance. The mechanisms linking obesity and the associated leptin resistance remain largely unclear. With various mouse models and a leptin neutralizing antibody, we demonstrated that hyperleptinemia is a driving force for metabolic disorders. A partial reduction of plasma leptin levels in the context of obesity restores hypothalamic leptin sensitivity and effectively reduces weight gain and enhances insulin sensitivity. These results highlight that a partial reduction in plasma leptin levels leads to improved leptin sensitivity, while pointing to a new avenue for therapeutic interventions in the treatment of obesity and its associated comorbidities. |
| Databáze: | OpenAIRE |
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