Association Between TP53 Gene Codon 72 Polymorphism and Acute Myeloid Leukemia Susceptibility: Evidence Based on a Meta-Analysis
| Autor: | Peiliang Geng, Qing-Ping Gao, Guo-Zheng Yu, Xian-Tao Zeng, Sheng Li, Xu-Bin Ao, Xiao-Lan Ruan, Xiang-Yu Meng |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Myeloid
Genotype Biology Risk Factors medicine Odds Ratio Humans Genetic Predisposition to Disease Codon Gene Genetics Polymorphism Genetic Case-control study Myeloid leukemia Reproducibility of Results General Medicine Odds ratio medicine.disease Genes p53 Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Leukemia Myeloid Meta-analysis Case-Control Studies Tumor Suppressor Protein p53 Meta-Analysis |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | BACKGROUND Many studies have reported that the p53 codon 72 polymorphism is associated with acute myeloid leukemia (AML) susceptibility; however, the conclusions are inconsistent. Therefore, we performed this meta-analysis to obtain a more precise result. MATERIAL AND METHODS We searched PubMed to identify relevant studies, and 6 published case-control studies were retrieved, including 924 AML patients and 3832 controls. Odds ratio (OR) with corresponding 95% confidence interval (95%CI) was applied to assess the association between p53 codon 72 polymorphism and AML susceptibility. The meta-analysis was performed with Comprehensive Meta-Analysis software, version 2.2. RESULTS Overall, no significant association between p53 codon 72 polymorphism and AML susceptibility was found in this meta-analysis (Pro vs. Arg: OR=0.94, 95%CI=0.81-1.10; Pro/Pro vs. Arg/Arg: OR=0.93, 95%CI=0.71-1.22; Arg/Pro vs. Arg/Arg: OR=0.79, 95%CI=0.55-1.13; (Pro/Pro + Arg/Pro) vs. Arg/Arg: OR=0.84, 95%CI=0.62-1.13; Pro/Pro vs. (Arg/Arg + Arg/Pro): OR=1.06, 95%CI=0.83-1.35). Similar results were also found in stratified analysis according to ethnicity and source of controls. CONCLUSIONS Our meta-analysis demonstrates that p53 codon 72 polymorphism may not be a risk factor for AML, which should be verified in future studies. |
| Databáze: | OpenAIRE |
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