Safe and effective booster immunization using DTaP in teenagers
| Autor: | Kazunari Kamachi, Tetsuo Nakayama, Takako Komiya, Motohide Takahashi, Kenji Okada, Akihiko Yamamoto, Takashi Nakano, Nobuhiko Okabe, Takao Nagai, Hitoshi Kamiya |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Local pain Pediatrics medicine.medical_specialty Adolescent Whooping Cough Immunization Secondary law.invention Japan Randomized controlled trial law Humans Medicine Child Diphtheria-Tetanus-Pertussis Vaccine Booster (rocketry) General Veterinary General Immunology and Microbiology business.industry Incidence Immunogenicity Incidence (epidemiology) Public Health Environmental and Occupational Health Antibodies Bacterial Vaccination Infectious Diseases Immunization Relative risk Molecular Medicine Female business |
| Zdroj: | Vaccine. 28:7626-7633 |
| ISSN: | 0264-410X |
| Popis: | The incidence of reported cases with pertussis has increased in young adults in Japan and the lack of additional booster immunizations containing pertussis components is suspected to be one of the causal reasons. Instead of DT immunization at 11-12 years of age, safety and immunogenicity were investigated using 0.2 ml and 0.5 ml of DTaP. 176 subjects in DTaP 0.5ml, 178 in DTaP 0.2 ml, and 197 in DT 0.1 ml groups were enrolled in clinical trial. The relative risk of local reactions in the DTaP 0.2 ml group compared to the DT 0.1 ml group was 1.13 (95% CI: 0.97-1.30), and that of the DTaP 0.5 ml to the DT 0.1 ml group was 1.34 (95% CI: 1.18-1.53). The relative risks of local pain and heat were 1.62 (95% CI: 1.33-1.98) and 1.59 (95% CI: 1.19-2.13), respectively, in the DTaP 0.5 ml group compared to the DT 0.1 ml group. Sero-positive rates against PT and FHA were 54% and 82% before immunization and increased to >95% for both after vaccination with no significant difference in GMT. Instead of the scheduled DT program, 0.2 ml of DTaP was acceptable and demonstrated efficient immunogenicity. |
| Databáze: | OpenAIRE |
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