Peripheral vasopressin but not oxytocin relates to severity of acute psychosis in women with acutely-ill untreated first-episode psychosis
| Autor: | Leah H. Rubin, Scot Hill, John A. Sweeney, Margret S.H. Harris, Hossein Pournajafi-Nazarloo, C. Sue Carter, James L. Reilly, Jeffrey R. Bishop |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Vasopressin Adolescent Vasopressins Neuropsychological Tests Oxytocin Verbal learning Article Young Adult Internal medicine medicine Humans Young adult Biological Psychiatry Psychiatric Status Rating Scales Analysis of Variance Sex Characteristics Learning Disabilities Verbal Learning medicine.disease Psychiatry and Mental health Endocrinology Psychotic Disorders Schizophrenia Acute Disease Linear Models Female Analysis of variance Psychology Hormone medicine.drug Sex characteristics |
| Zdroj: | Schizophrenia Research. 146:138-143 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2013.01.019 |
| Popis: | Background In women with chronic schizophrenia, higher levels of peripheral oxytocin have been associated with lower levels of positive but not negative symptoms. Sex-specific associations between endogenous levels of oxytocin (OT) and arginine vasopressin (AVP) with clinical symptoms and cognition in untreated early course patients have not been examined. Method Clinical ratings and neuropsychological testing were performed in thirty-eight acutely ill, unmedicated first-episode schizophrenia patients (14 women, 24 men). Serum hormone assays were obtained in patients and thirty-eight demographically similar healthy controls. Results Patients demonstrated increased AVP levels compared to controls (p = 0.01). Higher AVP levels were associated with greater positive symptoms (r = 0.58, p = 0.03) and worse verbal learning (r = − 0.63, p = 0.02) in female, but not male, patients. OT levels did not statistically differ between patients and controls, and were unrelated to clinical symptoms or cognition in patients. Conclusion Results suggest an association of endogenous AVP with increased positive symptom severity and worse cognition in untreated female, but not male, schizophrenia patients. Findings support the role of neuroendocrine alterations in acute psychosis and the importance of examining sex-specific neuroendocrine alterations early in the course of schizophrenia. |
| Databáze: | OpenAIRE |
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