Rechallenge of anti-PD-1/PD-L1 antibody showed a good response to metastatic breast cancer: a case report
| Autor: | Makiko Mizutani, Yoko Otani, Norikazu Masuda, Hiroyuki Yasojima, Nozomi Morikawa, Misato Masuyama, Masayuki Mano, Kiyoshi Mori |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Lung Neoplasms Paclitaxel Immunology Triple Negative Breast Neoplasms Pembrolizumab Antibodies Monoclonal Humanized B7-H1 Antigen 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Atezolizumab Albumins PD-L1 Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Immunology and Allergy Immune Checkpoint Inhibitors biology business.industry Cancer Middle Aged medicine.disease Metastatic breast cancer Treatment Outcome 030104 developmental biology chemistry Drug Resistance Neoplasm 030220 oncology & carcinogenesis Retreatment biology.protein Female Microsatellite Instability business Progressive disease Eribulin |
| Zdroj: | Immunotherapy. 13:189-194 |
| ISSN: | 1750-7448 1750-743X |
| DOI: | 10.2217/imt-2020-0242 |
| Popis: | Rechallenge of immune checkpoint inhibitors has been reported for neoplasms other than breast cancer. Reported here is a case of a 55-year old woman diagnosed as having triple-negative right breast cancer with multiple metastases including lung. Atezolizumab and nab-paclitaxel were administered followed by epirubicin–cyclophosphamide. With subsequent eribulin, the overall best response was progressive disease, and curative surgical resection was performed. Three months after surgery (1.5 years after initial response of lung metastasis), right lung metastasis emerged at a site different from baseline. Based on the microsatellite instability-high status, pembrolizumab was administered and showed a good response. The patient has been treated with pembrolizumab, maintaining partial response, for over 9 months, which suggests the benefit of immune checkpoint inhibitors rechallenge in breast cancer. |
| Databáze: | OpenAIRE |
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