A Meta-analysis of the Efficacy of Phototherapy in Tissue Repair
| Autor: | Chukuka S. Enwemeka, Keyuri B. Patel, Richard V. Lenz, Seema Dhimmer, Peter C. Douris, Andras M. Fulop, James R. Deluca, David D. Johanson |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Wound Healing medicine.medical_specialty business.industry Background data Biomedical Engineering Phototherapy Tissue repair Models Biological Surgery Experimental animal Treatment Outcome Text mining Meta-analysis Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Treatment effect business Statistic |
| Zdroj: | Photomedicine and Laser Surgery. 27:695-702 |
| ISSN: | 1557-8550 1549-5418 |
| DOI: | 10.1089/pho.2009.2550 |
| Popis: | The effect of phototherapy on tissue repair was determined by aggregating the literature and using statistical meta-analysis to analyze pertinent studies published between 2000 and 2007.Phototherapy has been used for more than 40 y; however, its efficacy on tissue repair remains contentious.Related original studies were gathered from every available source. The papers were then screened and coded; those meeting pre-established inclusion criterion were subjected to meta-analysis, using Cohen's d statistic to determine treatment effect size.Seventy effect sizes were computed from the 23 papers that met the inclusion criteria. The overall mean effect obtained was highly significant, d = +1.94 (95% confidence interval = 0.58-2.50). Further analyses revealed a similarly positive effect of phototherapy on tissue repair in experimental animal studies, d = +2.60, and a small to moderately positive effect in human cases of tissue repair, d = +0.34. The fail-safe number associated with the overall effect was 869; i.e., the number of additional studies in which phototherapy has negative or no effect on wound healing needed to negate the overall large effect size of + 1.94. The corresponding fail-safe numbers for experimental animal and human tissue repair studies were 612 and 64, respectively.These findings indicate that phototherapy is a highly effective form of treatment for tissue repair, with stronger supporting evidence resulting from experimental animal studies than human studies. |
| Databáze: | OpenAIRE |
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