Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
Autor: | Naglaa Fawaz, Samah R Al-Zeheimi, Said Y. ALKindi, Salam Alkindi, Anwaar R Al-Ghadani, Samir K. Ballas, Anil Pathare |
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Rok vydání: | 2021 |
Předmět: |
Adult
Medicine (General) medicine.medical_specialty pulmonary embolism Bilirubin medicine.medical_treatment Splenectomy Anemia Sickle Cell Biochemistry chemistry.chemical_compound R5-920 Risk Factors White blood cell Internal medicine medicine Humans In patient cardiovascular diseases Retrospective Studies business.industry Biochemistry (medical) Venous Thromboembolism Cell Biology General Medicine equipment and supplies medicine.disease Acute chest syndrome Pulmonary embolism medicine.anatomical_structure chemistry Case-Control Studies sickle cell disease business Venous thromboembolism Central venous catheter Retrospective Clinical Research Report |
Zdroj: | Journal of International Medical Research, Vol 49 (2021) The Journal of International Medical Research |
ISSN: | 1473-2300 0300-0605 |
Popis: | Objective To assess the clinical and laboratory predictors of venous thromboembolism (VTE) in patients with sickle cell anaemia (SCA) and its relationship to morbidity and mortality. Methods This retrospective case–control study analysed data from patients with SCA that experienced VTE compared with matched control patients with SCA but no VTE (2:1 ratio). Results A total of 102 patients with SCA were enrolled (68 cases with VTE and 34 controls). Amongst the 68 cases (median age, 29.5 years), 26 (38.2%) presented with isolated pulmonary embolism (PE). A higher prevalence of splenectomy (73.5% versus 35.3%) was observed in the cases compared with the controls. A significantly higher prevalence of central venous catheter (CVC) insertion (42.6% versus 8.8%) was observed in the cases compared with the controls. High white blood cell counts, serum lactic dehydrogenase (LDH), bilirubin and C-reactive protein (CRP) and low haemoglobin (Hb) and HbF were significant risk factors for VTE. Forty-two cases (61.8%) developed acute chest syndrome, 10 (14.7%) had a stroke and seven (10.3%) died. Conclusions VTE in patients with SCA has a high impact on morbidity and mortality. PE was the leading presentation of VTE, with CVC insertion, high LDH, bilirubin, CRP and white blood cell counts along with low Hb and HbF constituting other significant risk factors. |
Databáze: | OpenAIRE |
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