Plasmodium berghei: antiparasitic effects of orally administered hypoestoxide in mice
| Autor: | Howard B. Cottam, Olusola A. Oyemade, Akinbo A. Adesomoju, Joseph I. Okogun, Emeka J. Nchekwube, Emmanuel A. Ojo-Amaize |
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| Rok vydání: | 2006 |
| Předmět: |
Ratón
Antiparasitic medicine.drug_class Plasmodium berghei Immunology Administration Oral Parasitemia Pharmacology chemistry.chemical_compound Antimalarials Mice In vivo Chloroquine medicine Animals biology General Medicine Glutathione biology.organism_classification medicine.disease In vitro Malaria Disease Models Animal Infectious Diseases chemistry Parasitology Female Diterpenes medicine.drug |
| Zdroj: | Experimental parasitology. 117(2) |
| ISSN: | 0014-4894 |
| Popis: | Hypoestoxide (HE) is a diterpene isolated from Hypoestes rosea (Acanthaceae), a plant indigenous to Nigeria. Previous studies demonstrated that HE exhibited potent anti-inflammatory and anti-cancer activities in well established animal models but weak in vitro activities in both the anti-inflammation and anti-cancer in vitro screening systems. We now report a similar observation in the in vitro and in vivo screening systems for antimalarial activity. The results indicate that while HE exhibits a relatively weak in vitro activity (IC(50) = 10 microM versus 0.11 microM for chloroquine) against different strains of cultured P. falciparum parasites, the dose of HE required to reduce parasitemia by 90% in Plasmodium berghei-infected mice, is much lower than standard antimalaria drugs (SD(90) = 250 microg/kg versus 5mg/kg for chloroquine). Furthermore, lower doses of HE were much more effective than higher doses in inhibiting parasite development. The implications of these findings are discussed. |
| Databáze: | OpenAIRE |
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