Parent-Reported Symptoms of Sleep-Disordered Breathing Are Associated With Increased Behavioral Problems at 2 Years of Age: The Canadian Healthy Infant Longitudinal Development Birth Cohort Study
| Autor: | Padmaja Subbarao, Jacqueline Pei, Allan B. Becker, Malcolm R. Sears, Joyce Chikuma, Piush J. Mandhane, Child Study Investigators, Lisa Smithson, Sukhpreet K Tamana, Stuart E. Turvey, Jennifer Mariasine, Diana L. Lefebvre, Amanda Lau, Rochelle Young |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Parents Canada Pediatrics medicine.medical_specialty Polysomnography Child Behavior Disorders Cohort Studies 03 medical and health sciences Sleep Apnea Syndromes 0302 clinical medicine Pregnancy Surveys and Questionnaires 030225 pediatrics Physiology (medical) mental disorders Epidemiology Humans Medicine Longitudinal Studies Age of Onset Child Child Behavior Checklist Depression (differential diagnoses) Problem Behavior medicine.diagnostic_test business.industry Infant Sleep apnea medicine.disease nervous system diseases respiratory tract diseases 3. Good health Longitudinal development Child Preschool Anxiety Female Neurology (clinical) medicine.symptom Age of onset Sleep Disordered Breathing Sleep business 030217 neurology & neurosurgery |
| Zdroj: | Sleep. 41 |
| ISSN: | 1550-9109 0161-8105 |
| Popis: | Study objectives To examine the association between the age of onset and duration of parent-reported symptoms of sleep-disordered breathing (SDB) and behavioral problems at age 2. Methods Parent-reported SDB symptoms were assessed quarterly between 3 months and 2 years among 583 Canadian Healthy Infant Longitudinal Development Edmonton-site participants. Parent-reported SDB symptoms were clustered into phenotypes using group-based trajectory analysis based on age of onset and duration of symptoms. Home-based polysomnography (PSG) was completed at 1 year. The Child Behavior Checklist preschool-version (Mean T-score 50, standard deviation 10 points) assessed total, externalizing (attention), and internalizing (anxiety, depression) behaviors at 2 years. Results Four phenotypes were identified: no SDB (64.7%), early-onset SDB (15.7%, peak symptoms at 9 months), late-onset (14.2%, peak symptoms at 18 months), and persistent SDB symptoms (5.3%, peak symptoms from 3 through 24 months). Persistent SDB (9.5 points, 95% CI 1.7, 17.2; p = .02) predicted the greatest magnitude of effect of total behavior problems, compared with children without SDB. Children with early-onset SDB (3.5 points, 95% CI 1.6, 5.4; p ≤ .001) and late-onset SDB (6.1 points 95% CI 4.0, 8.3; p ≤ .001) had increased total behavioral problems than children without SDB to 2 years. Additional analyses showed that the SDB phenotypes' trajectories were important for internalizing but not for externalizing behavior problems. There were no significant associations between home-PSG and parent-reported behavior problems. Conclusions Findings suggest that the age of onset and duration of parent-reported SDB symptoms prior to age 2 have adverse consequences for overall behavior problems. |
| Databáze: | OpenAIRE |
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