Serum levels of TDP-43 in late-life patients with depressive episode
| Autor: | Takahisa Shimano, Hitoshi Maeshima, Megumi Inoue, Toshihito Suzuki, Hajime Baba, Mei Ishiguro, Heii Arai, Seita Yasuda, Hiroko Shukuzawa, Tomoya Ichikawa |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Enzyme-Linked Immunosorbent Assay Age and sex 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Humans Bipolar disorder Major depressive episode Depression (differential diagnoses) Aged Aged 80 and over Depressive Disorder Major business.industry Mood Disorders Prodromal Stage TAR DNA-BINDING PROTEIN Healthy subjects nutritional and metabolic diseases Middle Aged medicine.disease nervous system diseases 030227 psychiatry DNA-Binding Proteins Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Clinical Psychology Frontotemporal Dementia Female medicine.symptom business 030217 neurology & neurosurgery Biomarkers Frontotemporal dementia |
| Zdroj: | Journal of affective disorders. 250 |
| ISSN: | 1573-2517 |
| Popis: | Background Recent reports have suggested a relationship between affective disorder including depression and bipolar disorder (BP) and frontotemporal dementia (FTD). TAR DNA binding protein (TDP) -43 is a protein found in the brain and peripheral fluid of patients with FTD. To examine a possible association between affective disorders and FTD, serum levels of TDP-43 were evaluated in late-life patients with major depressive episode (MDE). Methods The subjects were 74 late-life (≥50 years old) inpatients with DSM-IV or -5 MDE (58 had major depressive disorders and 16 had BP) and 58 healthy subjects. Patients were recruited from Juntendo Koshigaya Hospital, Saitama, Japan, between January 2005 and May 2017. Serum TDP-43 levels were measured using an ELISA kit. Results Serum levels of TDP-43 were significantly higher in the MDE group than the control group independent of age and sex. Limitations All patients were on antidepressant medication. Conclusions Our finding suggests that some depressive patients may be in a prodromal stage of FTD or very-early stage of FTD comorbid with depression. |
| Databáze: | OpenAIRE |
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