Topoisomerase IIa Protein Expression Patterns in Laryngeal Squamous Cell Carcinoma
| Autor: | Vasileios Ragos, Evangelos Tsiambas, Dimitrios Peschos, Vasileios Papanikolaou, Efthymios Kyrodimos, Dimitrios Roukas, Chara Stavraka, Nicholas S Mastronikolis, Aristeidis Chrysovergis |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_treatment Breast Adenocarcinoma Carcinoma medicine Humans Stage (cooking) Laryngeal Neoplasms Gene Chemotherapy biology business.industry Topoisomerase General Medicine Middle Aged medicine.disease Laryngeal squamous cell carcinoma DNA Topoisomerases Type II Oncology Carcinoma Squamous Cell Cancer research biology.protein Immunohistochemistry Female business |
| Zdroj: | Anticancer Research. 40:807-811 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | BACKGROUND/AIM Topoisomerase II alpha (TopoIIa) is a critical gene associated with response to chemo-therapeutic agents, such as anthracyclines, especially in breast adenocarcinoma. The aim of this study was to investigate the role of aberrant TopoIIa protein expression in laryngeal squamous cell carcinoma (LSCC). MATERIALS AND METHODS Fifty (n=50) LSCC cases were enrolled in the study. Immunohistochemistry and a digital image analysis assay were implemented. RESULTS TopoIIa protein overexpression was observed in 32/50 (64%) cases, whereas low expression rates were detected in 18/50 (36%). TopoIIa overall expression presented strong association with the grade of the examined malignant tissues and borderline association with stage. TopoIIa overexpression correlated also with Human papillomavirus (HPV) positivity. CONCLUSION TopoIIa overexpression was observed in significant subsets of LSCCs, and correlated predominantly with the grade of differentiation. HPV persistent infection seems to be associated with increased TopoIIa protein expression. TopoIIa expression analysis appears to be critical in identifying sub-groups of patients eligible for specific chemotherapy. |
| Databáze: | OpenAIRE |
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